Global incidence, risk factors, and temporal trends of nasal cancer: A population-based analysis

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-04-17 DOI:10.1002/cam4.70163

Junjie Huang, Wing Sze Pang, Fung Yu Mak, Sze Chai Chan, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno III, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong, NCD Global Health Research Group, Association of Pacific Rim Universities (APRU)

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Abstract

Background

Nasal cancer is a rare and fatal disease, with an incidence rate of <1 in 100,000, and a 5-year survival rate of around 30%. The study aims to investigate the worldwide disease burden, associated risk factors, and temporal incidence patterns of nasal cancer.

Methods

Data were obtained from multiple sources, including the Global Cancer Observatory, Cancer Incidence in Five Continents Plus, the Global Burden of Disease database, the World Bank, and the United Nations. The study utilized multivariable linear regression to investigate the relationship between risk factors and the incidence of nasal cancer by age for each country. Trend analysis was conducted using the joinpoint regression analysis program, and the average annual percentage change (AAPC) was calculated. The accuracy of trend estimations was assessed using the 95% confidence interval (CI). Additionally, the incidence of nasal cancer was examined by age and geographic location.

Results

A total of 37,674 new cases were reported in 2020 (ASR 4.2 per 1,000,000). The highest ASRs were observed in South-Eastern Asia (5.3) and Central and Eastern Europe (4.8). A number of risk factors were identified, such as higher HDI regions, higher prevalence of smoking, alcohol drinking, unhealthy dietary, and hypertension. In addition, physical inactivity was related to lower incidence. An overall decreasing trend was reported in the global population, but an increasing trend was discovered in males.

Conclusions

The highest burden of nasal cancer was found in South-Eastern Asia and Central and Eastern Europe, potentially due to regional genetic factors and pollution issues. Targeted interventions are need in high-risk regions. Further studies are needed to investigate factors contributing to the increasing temporal trend of nasal cancer among the male population.

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全球鼻癌发病率、危险因素和时间趋势：基于人群的分析

鼻癌是一种罕见且致命的疾病，发病率为10万分之一，5年生存率约为30%。本研究旨在调查世界范围内鼻癌的疾病负担、相关危险因素和时间发病模式。方法数据来自多个来源，包括全球癌症观测站、五大洲癌症发病率、全球疾病负担数据库、世界银行和联合国。本研究利用多变量线性回归分析了各国不同年龄的鼻癌发病率与危险因素之间的关系。采用结合点回归分析程序进行趋势分析，计算年均百分比变化（AAPC）。使用95%置信区间（CI）评估趋势估计的准确性。此外，还根据年龄和地理位置检查了鼻癌的发病率。结果2020年共报告新发病例37674例（ASR 4.2 / 100万）。asr最高的是东南亚（5.3）和中欧和东欧（4.8）。确定了许多危险因素，如人类发展指数较高的地区、吸烟、饮酒、不健康饮食和高血压的患病率较高。此外，缺乏运动与发病率较低有关。据报道，全球人口总体呈下降趋势，但男性呈上升趋势。结论东南亚和中东欧地区鼻癌负担最高，可能与区域遗传因素和污染问题有关。高风险地区需要有针对性的干预措施。需要进一步的研究来调查导致男性人群中鼻癌的时间趋势增加的因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.