{"title":"Measurement and Correlation of Deferiprone Solubility in 1-Propanol and Water Solvent Mixtures at Different Temperatures","authors":"Homa Rezaei, Elaheh Rahimpour, Fleming Martinez, Abolghasem Jouyban","doi":"10.3103/S0027131424700548","DOIUrl":null,"url":null,"abstract":"<p>This article dealt with the saturated solubility values of deferiprone (which is an iron chelator agent) in aqueous mixtures of 1-propanol using experimental measurements as well as mathematical correlations. The solubility of deferiprone demonstrated a positive correlation with temperature and 1-propanol content. Four mathematical models were employed to correlate the solid-liquid equilibrium data, and the fitting results demonstrated that the computed solubility results from the employed computational cosolvency models were in good agreement with the experimental data. It was anticipated that these experimental solubilities, density values, and correlation results can be employed for pharmaceutical development such as purification, drug manufacturing, crystallization, and extraction on an industrial scale as well as in theoretical research.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 1","pages":"48 - 54"},"PeriodicalIF":0.7000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Moscow University Chemistry Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.3103/S0027131424700548","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
This article dealt with the saturated solubility values of deferiprone (which is an iron chelator agent) in aqueous mixtures of 1-propanol using experimental measurements as well as mathematical correlations. The solubility of deferiprone demonstrated a positive correlation with temperature and 1-propanol content. Four mathematical models were employed to correlate the solid-liquid equilibrium data, and the fitting results demonstrated that the computed solubility results from the employed computational cosolvency models were in good agreement with the experimental data. It was anticipated that these experimental solubilities, density values, and correlation results can be employed for pharmaceutical development such as purification, drug manufacturing, crystallization, and extraction on an industrial scale as well as in theoretical research.
期刊介绍：
Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
