Initial Validation of the Eosinophilic Gastritis and Gastroenteritis Quality of Life Scale

Gastro hep advances Pub Date : 2025-01-01 DOI:10.1016/j.gastha.2025.100627

Tiffany H. Taft , Ikuo Hirano , Nirmala Gonsalves

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Abstract

Background and Aims

Eosinophilic gastrointestinal disorders (EGIDs) are chronic immune-mediated conditions characterized by gastrointestinal symptoms and gut eosinophilia. Health-related quality of life (HRQoL) is an important metric to understand patient outcomes; the only disease-specific measure of HRQoL exists for eosinophilic esophagitis (EoE) patients. Patients with non-EoE EGIDs experience unique symptoms and treatment options and disease burden of these rare disorders is under-recognized and considered significant. We aim to validate a new measure of HRQoL specific for adults with non-EoE EGIDs.

Methods

The Eosinophilic Gastritis and Gastroenteritis Quality of Life Scale (EGGE-QOL) is 20-items scale developed from patient qualitative interviews assessing HRQoL over the past month. Adult patients were recruited from an academic setting and patient advocacy groups to complete an online questionnaire. Psychometric assessment of the EGGE-QOL included reliability measures (internal consistency, split-half reliability), criterion validity (exploratory factor analysis), and concurrent validity (correlations with EGID symptoms, anxiety, depression, fatigue, and sleep disturbance).

Results

Forty-one participants completed the study. The EGGE-QOL had excellent reliability (>0.90). Exploratory factor analysis identified a single structure with 3 possible items for removal. Concurrent validity was supported by moderate to large correlations with psychological symptoms, fatigue and sleep, and symptom severity, frequency, and duration. The most important symptom that impacts non-EoE EGID HRQoL may be frequent diarrhea.

Conclusion

The EGGE-QOL is a reliable and valid measure of HRQoL for adults with non-EoE EGIDs, representing an important step in understanding the experiences of these patients and assessing how these conditions may impact daily function. Additional studies are necessary to confirm these findings in larger, diverse cohorts.

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嗜酸性胃炎和胃肠炎生活质量量表的初步验证

背景和目的嗜酸性粒细胞胃肠病（EGIDs）是由免疫介导的慢性疾病，以胃肠道症状和肠道嗜酸性粒细胞增多为特征。健康相关生活质量（HRQoL）是了解患者预后的一个重要指标；嗜酸性粒细胞性食管炎（EoE）患者的健康相关生活质量是唯一针对特定疾病的测量指标。非嗜酸性粒细胞食管炎（EoE）患者有独特的症状和治疗选择，这些罕见疾病造成的疾病负担未得到充分认识和重视。方法嗜酸性胃炎和胃肠炎生活质量量表（EGGE-QOL）由 20 个项目组成，通过对患者进行定性访谈，评估其过去一个月的生活质量。研究人员从学术机构和患者权益组织中招募成年患者填写在线问卷。对 EGGE-QOL 的心理计量学评估包括信度测量（内部一致性、分半信度）、标准效度（探索性因子分析）和并发效度（与 EGID 症状、焦虑、抑郁、疲劳和睡眠障碍的相关性）。EGGE-QOL 具有极佳的可靠性（0.90）。探索性因子分析确定了一个单一结构，其中有 3 个可能删除的项目。与心理症状、疲劳和睡眠，以及症状的严重程度、频率和持续时间之间存在中度到高度的相关性，从而证明了并发有效性。结论EGGE-QOL是一种可靠有效的非EoE EGID成人患者HRQoL测量方法，是了解这些患者的经历和评估这些疾病如何影响日常功能的重要一步。有必要进行更多的研究，以便在更大规模、更多样化的队列中证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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