Risk factors of central compartment lymph node metastasis posterior to the right recurrent laryngeal nerve in differentiated thyroid carcinoma: A single-center prospective study in Vietnam

Q3 Medicine
Phan Hoang Hiep , Tran Ngoc Luong , Doan Quoc Hung , Tran Doan Ket , Pham Quyet Thang , Do Van Ky , Nguyen Giang Son , Truong Quang Huy , Ngo Van Thanh , Do Trung Anh , Doan Vu Tu Quyen
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Abstract

The study aims to examine the incidence of central compartment lymph node metastasis on the right side posterior to the recurrent laryngeal nerve in cases of papillary thyroid cancer, as well as the risk factors that may increase this incidence. A total thyroidectomy was conducted on 230 patients diagnosed with differentiated thyroid cancer, accompanied by right central compartment lymph node dissection at Viet Nam National hospital of endocrinology in 2024. The central lymph nodes were categorized into two groups: pre-nerve lymph nodes and post-nerve lymph nodes. The clinical and paraclinical characteristics of the primary tumor and metastatic cervical lymph nodes were documented. The result showed that 52 cases (22.6 %) presenting metastatic lymph nodes. Age >55 years, female gender, tumor size exceeding 1 cm, concurrent thyroiditis, and metastasis to pre-nerve central lymph nodes and ipsilateral lateral neck lymph nodes were significantly correlated with elevated rates of metastasis to lymph nodes located posterior to the recurrent laryngeal nerve (p < 0.05). Tumor location, multifocality, and extrathyroidal invasion did not significantly influence the metastasis rate to post-nerve lymph nodes (p > 0.05). Multivariate regression analysis revealed four independent prognostic factors for post-nerve lymph node metastasis: tumor size exceeding 1 cm, concurrent chronic thyroiditis, metastasis to pre-nerve lymph nodes, and metastasis to ipsilateral lateral neck lymph nodes. In conclusion, patient with above characteristics, precise dissection is recommended to prevent the oversight of metastatic lymph nodes.
分化型甲状腺癌中央间室淋巴结转移至右喉返神经后方的危险因素:越南的一项单中心前瞻性研究
本研究旨在探讨甲状腺乳头状癌右侧喉返神经后侧中央室淋巴结转移的发生率,以及可能增加该发生率的危险因素。本文于2024年在越南国立内分泌医院对230例诊断为分化型甲状腺癌并伴有右侧中央室淋巴结清扫的患者行甲状腺全切除术。中枢淋巴结分为两组:神经前淋巴结和神经后淋巴结。记录了原发肿瘤和转移性颈部淋巴结的临床和临床旁特征。结果显示52例(22.6%)出现转移性淋巴结。年龄55岁、女性、肿瘤大小超过1cm、并发甲状腺炎、神经前中枢淋巴结和同侧颈部外侧淋巴结转移与喉返神经后淋巴结转移率升高显著相关(p <;0.05)。肿瘤的位置、多灶性和甲状腺外浸润对神经后淋巴结转移率无显著影响(p >;0.05)。多因素回归分析显示神经后淋巴结转移的4个独立预后因素:肿瘤大小超过1cm、并发慢性甲状腺炎、神经前淋巴结转移、同侧颈外淋巴结转移。综上所述,对于具有上述特征的患者,建议进行精确的淋巴结清扫,以防止转移淋巴结被忽视。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Endocrine and Metabolic Science
Endocrine and Metabolic Science Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
2.80
自引率
0.00%
发文量
4
审稿时长
84 days
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