Analysis of factors influencing chemotherapy-induced peripheral neuropathy in breast cancer patients using a random forest model

IF 5.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Pub Date : 2025-04-11 DOI:10.1016/j.breast.2025.104457

Huiqian Xu , Hong Li , Yijing Fan , Yaqi Wang , Zeyuan Li , Lizhi Zhou , Xijun Hao

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引用次数: 0

Abstract

Objective

This study aimed to analyze the factors influencing chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer patients, identify modifiable factors, and provide a theoretical basis for targeted interventions.

Methods

A total of 542 patients with breast cancer who were hospitalized for chemotherapy in multiple hospitals from September 2022 to September 2023 were selected as the study objects. Data were collected using questionnaires covering demographic characteristics, disease-related information, lifestyle, and psychological status. Lasso-logistic regression was employed to identify influencing factors, and a random forest model was used to rank the importance of variables.

Results

Lasso-logistic regression analysis identified age, BMI, cumulative chemotherapy dose, hypertension, physical activity level, and depression as significant factors associated with CIPN (P < 0.05). The variable importance ranking from the random forest model was as follows: age, BMI, cumulative chemotherapy dose, physical activity, hypertension, and depression.

Conclusion

Early identification of high-risk CIPN patients is crucial for guiding clinical nursing practices. These findings provide a foundation for the management and intervention of CIPN in breast cancer patients.

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使用随机森林模型分析乳腺癌患者化疗诱导周围神经病变的影响因素

目的分析乳腺癌患者化疗诱导的周围神经病变（CIPN）的影响因素，找出可改变的因素，为针对性干预提供理论依据。方法选取2022年9月至2023年9月在多家医院住院化疗的542例乳腺癌患者作为研究对象。数据通过问卷收集，包括人口特征、疾病相关信息、生活方式和心理状态。采用Lasso-logistic回归识别影响因素，采用随机森林模型对变量重要性进行排序。结果logistic回归分析发现，年龄、BMI、累积化疗剂量、高血压、体力活动水平和抑郁是CIPN的显著相关因素(P <；0.05)。随机森林模型的变量重要性排序如下：年龄、BMI、累积化疗剂量、体力活动、高血压和抑郁。结论早期识别CIPN高危患者对指导临床护理至关重要。这些发现为乳腺癌患者CIPN的管理和干预提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast 医学-妇产科学

CiteScore

8.70

自引率

2.60%

发文量

165

审稿时长

59 days

期刊介绍： The Breast is an international, multidisciplinary journal for researchers and clinicians, which focuses on translational and clinical research for the advancement of breast cancer prevention, diagnosis and treatment of all stages.