Zhonghua Luo MD , Zhenping Li MD , Yuefeng Yu MD , Yan Lu MD, PhD , Yangyang Du MMed , Xiaolan Xiang MMed , Caijuan Lin MMed , Kun Xu MMed , Yue Xu MD, PhD , Jingjing Huang MD, PhD , Shanshan Yu MD , Yuqing Lan MD, PhD , Xiaoling Liang MD, PhD
{"title":"Profiles of Choroidal Vortex Vein Drainage System Using Ultra-Widefield OCT Angiography in a Chinese Population","authors":"Zhonghua Luo MD , Zhenping Li MD , Yuefeng Yu MD , Yan Lu MD, PhD , Yangyang Du MMed , Xiaolan Xiang MMed , Caijuan Lin MMed , Kun Xu MMed , Yue Xu MD, PhD , Jingjing Huang MD, PhD , Shanshan Yu MD , Yuqing Lan MD, PhD , Xiaoling Liang MD, PhD","doi":"10.1016/j.xops.2025.100768","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>To develop a normative profile for choroidal vortex vein systems based on ultra-widefield OCT angiography (UWF-OCTA) in a healthy Chinese population.</div></div><div><h3>Design</h3><div>A cross-sectional, multicenter study.</div></div><div><h3>Participants</h3><div>A total of 515 eyes of 515 Chinese adults (515 healthy eyes) aged ≥20 years were recruited from the Choroidal Vortex Vein System Study.</div></div><div><h3>Methods</h3><div>All participants underwent comprehensive ophthalmic examinations. The 2-dimensional and 3-dimensional choroidal parameters of the vortex vein system were measured in each vortex vein drainage quadrant (24 × 20 mm<sup>2</sup> scan mode; central, superotemporal [ST], superonasal [SN], inferonasal [IN], and inferotemporal [IT] quadrants) using a UWF-OCTA device. The normative profile examined the choroidal parameters' fifth and 95th percentile values. The associations of ocular and systemic factors with choroidal parameters were investigated using multivariable linear regression to account for the correlation.</div></div><div><h3>Main Outcome Measures</h3><div>Choroidal thickness, choroidal vascularity index (CVI), choroidal vascular volume (CVV), and choroidal stromal volume (CSV).</div></div><div><h3>Results</h3><div>The fifth and 95th percentile values of the choroidal parameter dataset for the peripheral choroidal vortex vein system were set. The mean values of the peripheral choroidal vortex vein system parameters (choroidal thickness, CVI, CVV, and CSV) decreased with age, with a significant decline after 50 years. An association was observed between an increased axial length elongation and a thinner choroid layer in the macular region and the ST drainage system (all <em>P</em> < 0.01). The CVI was significantly correlated with gender in the ST vortex vein drainage system (coefficient: −1.02, <em>P</em> = 0.04).</div></div><div><h3>Conclusions</h3><div>We report a normative choroidal parameter dataset for the peripheral choroidal vortex vein system in a large Chinese cohort. Choroidal vessels and stroma in vortex vein drainage systems decrease with age, more remarkably after the age of 50 years.</div></div><div><h3>Financial Disclosure(s)</h3><div>The author(s) have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":74363,"journal":{"name":"Ophthalmology science","volume":"5 4","pages":"Article 100768"},"PeriodicalIF":3.2000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmology science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666914525000661","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose
To develop a normative profile for choroidal vortex vein systems based on ultra-widefield OCT angiography (UWF-OCTA) in a healthy Chinese population.
Design
A cross-sectional, multicenter study.
Participants
A total of 515 eyes of 515 Chinese adults (515 healthy eyes) aged ≥20 years were recruited from the Choroidal Vortex Vein System Study.
Methods
All participants underwent comprehensive ophthalmic examinations. The 2-dimensional and 3-dimensional choroidal parameters of the vortex vein system were measured in each vortex vein drainage quadrant (24 × 20 mm2 scan mode; central, superotemporal [ST], superonasal [SN], inferonasal [IN], and inferotemporal [IT] quadrants) using a UWF-OCTA device. The normative profile examined the choroidal parameters' fifth and 95th percentile values. The associations of ocular and systemic factors with choroidal parameters were investigated using multivariable linear regression to account for the correlation.
Main Outcome Measures
Choroidal thickness, choroidal vascularity index (CVI), choroidal vascular volume (CVV), and choroidal stromal volume (CSV).
Results
The fifth and 95th percentile values of the choroidal parameter dataset for the peripheral choroidal vortex vein system were set. The mean values of the peripheral choroidal vortex vein system parameters (choroidal thickness, CVI, CVV, and CSV) decreased with age, with a significant decline after 50 years. An association was observed between an increased axial length elongation and a thinner choroid layer in the macular region and the ST drainage system (all P < 0.01). The CVI was significantly correlated with gender in the ST vortex vein drainage system (coefficient: −1.02, P = 0.04).
Conclusions
We report a normative choroidal parameter dataset for the peripheral choroidal vortex vein system in a large Chinese cohort. Choroidal vessels and stroma in vortex vein drainage systems decrease with age, more remarkably after the age of 50 years.
Financial Disclosure(s)
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
