Front Cover: The Biarylitides: Understanding the Structure and Biosynthesis of a Fascinating Class of Cytochrome P450 Modified RiPP Natural Products (ChemBioChem 7/2025)
Leo Padva, Jemma Gullick, Laura J. Coe, Mathias H. Hansen, James J. De Voss, Max Crüsemann, Max J. Cryle
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引用次数: 0
Abstract
The cytochromes P450 are a powerful class of heme-containing enzymes capable of a wide range of oxidative transformations in nature. A potent example of their power is their role in the biosynthesis of the biarylitides, a class of ribosomal encoded peptide natural products. This cover image draws an analogy with black holes to highlight the power of these enzymes in their demonstrated ability to catalyse peptide crosslinking even when fluorine is present. More details can be found in article 10.1002/cbic.202400916 by James J. De Voss, Max Crüsemann, Max J. Cryle, and co-workers.. Image created by Dr. Yongwei Zhao.
细胞色素P450是一类功能强大的含血红素酶，在自然界中能够进行广泛的氧化转化。它们的力量的一个有力的例子是它们在生物合成双核蛋白中的作用，双核蛋白是一类核糖体编码的肽天然产物。这张封面图片与黑洞进行了类比，以突出这些酶的能力，即使在氟存在的情况下，它们也能催化肽交联。更多细节可以在第10.1002/ cic条中找到。202400916作者：James J. De Voss, Max crsemann, Max J. Cryle及其同事。图片由赵永伟博士制作。
期刊介绍：
ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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