{"title":"Frontispiz: Multicomponent Reaction Integrating Selenium(II)–Nitrogen Exchange (SeNEx) Chemistry and Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC)","authors":"","doi":"10.1002/ange.202581662","DOIUrl":null,"url":null,"abstract":"<p>Selenium-nitrogen exchange (SeNEx) chemistry has been seamlessly integrated with CuAAC. In their Research Article (e202500942), Wei Hou, Wei Zhou, Hongtao Xu et al. report a novel three-component reaction involving benzoselenazolones, alkynes, and azides. This reaction proceeds via a unique SeNEx–CuAAC tandem pathway, providing direct access to diverse 1,4,5-trisubstituted 5-seleno-1,2,3-triazoles regioselectively with high atom economy. It was applied to successfully identify a potent Escherichia coli β-glucuronidase inhibitor through target-based screening.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 16","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202581662","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angewandte Chemie","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ange.202581662","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Selenium-nitrogen exchange (SeNEx) chemistry has been seamlessly integrated with CuAAC. In their Research Article (e202500942), Wei Hou, Wei Zhou, Hongtao Xu et al. report a novel three-component reaction involving benzoselenazolones, alkynes, and azides. This reaction proceeds via a unique SeNEx–CuAAC tandem pathway, providing direct access to diverse 1,4,5-trisubstituted 5-seleno-1,2,3-triazoles regioselectively with high atom economy. It was applied to successfully identify a potent Escherichia coli β-glucuronidase inhibitor through target-based screening.
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