The diagnostic significance of immunohistochemical expression of SOX10 and TRPS1 in triple negative breast cancer

IF 1.5 4区医学 Q3 PATHOLOGY

Annals of Diagnostic Pathology Pub Date : 2025-04-09 DOI:10.1016/j.anndiagpath.2025.152480

Shaimaa Abdelraouf Elgohary, Maissa Noureldin Elmaraghy, Ola Hassan Nada, Rola Mohamed Farid, Sara Elshaarawi, Bakinam Mohamed Ashoush, Thanaa Elsayed Helal

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引用次数: 0

Abstract

Triple negative breast cancer (TNBC) usually exhibits heterogeneous morphological features. The absence of a specific targeted marker for the breast origin of TNBC makes the diagnosis of metastatic TNBC challenging. TRPS1 is regarded as a diagnostic marker for breast cancer of various subtypes, including the basal type of TNBC. SOX10 has been recorded in to be highly expressed in TNBCs. Our cohort study aimed to: first, assess the diagnostic value of TRPS1 and SOX10 immunohistochemical (IHC) expression in TNBC; second, investigate if any of these two markers are related to the established pathological factors of prognostic significance. The study cohort comprised 84 TNBC cases subjected to TRPS1 and SOX10 IHC staining. TRPS1 expression was demonstrated in 86.9 % of the cases. It was expressed in 85.9 %, 83.3 %, and 100 % of invasive breast carcinoma-no special type (IBC-NST), metaplastic carcinomas, and IBC with medullary pattern, respectively. SOX10 expression was identified in 61.9 % of the cases. Most (85.7 %) of IBC with medullary pattern and 83.3 % of metaplastic carcinomas showed positive SOX10 expression. Evaluation of the combined expression of both markers revealed that 52.4 %, 34.5 %, 9.5 %, and 3.6 % of TNBC cases were SOX10+/TRPS1+, SOX10-/TRPS1+, SOX10+/TRPS1-, and SOX10-/TRPS1-, respectively. TRPS1 and SOX10 are fairly sensitive markers for the diagnosis of TNBC. Accordingly, they may be of help in the detection of metastatic TNBC. However, additional studies are required to evaluate these markers on non-breast tumor tissue to further investigate their specificity.

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免疫组化表达SOX10和TRPS1在三阴性乳腺癌中的诊断意义

三阴性乳腺癌（TNBC）通常具有异质性形态特征。由于缺乏针对 TNBC 乳腺来源的特异性靶向标记物，因此诊断转移性 TNBC 具有挑战性。TRPS1被认为是包括TNBC基底型在内的各种亚型乳腺癌的诊断标志物。据记录，SOX10在TNBC中高表达。我们的队列研究旨在：首先，评估TRPS1和SOX10免疫组化（IHC）表达在TNBC中的诊断价值；其次，研究这两个标记物是否与具有预后意义的既定病理因素相关。研究队列包括84例进行了TRPS1和SOX10 IHC染色的TNBC病例。86.9%的病例有TRPS1表达。在浸润性乳腺癌-无特殊类型（IBC-NST）、移行细胞癌和髓质型IBC中，TRPS1的表达率分别为85.9%、83.3%和100%。61.9%的病例有 SOX10 表达。大多数（85.7%）髓样 IBC 和 83.3%的移行细胞癌显示 SOX10 阳性表达。对两种标记物联合表达的评估显示，52.4%、34.5%、9.5%和3.6%的TNBC病例分别为SOX10+/TRPS1+、SOX10-/TRPS1+、SOX10+/TRPS1-和SOX10-/TRPS1-。TRPS1和SOX10是诊断TNBC相当敏感的标志物。因此，它们可能有助于检测转移性TNBC。不过，还需要对非乳腺肿瘤组织的这些标记物进行评估，以进一步研究其特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Diagnostic Pathology 医学-病理学

CiteScore

3.90

自引率

5.00%

发文量

149

审稿时长

26 days

期刊介绍： A peer-reviewed journal devoted to the publication of articles dealing with traditional morphologic studies using standard diagnostic techniques and stressing clinicopathological correlations and scientific observation of relevance to the daily practice of pathology. Special features include pathologic-radiologic correlations and pathologic-cytologic correlations.