The mechanism of EGF in promoting skeletal muscle post-injury regeneration

IF 2.2 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2025-04-07 DOI:10.1016/j.diff.2025.100862

Huaixin Teng , Yongze Liu , Ruotong Hao , Lu Zhang , Xiaoyu Zhang , Shufeng Li , Shuang Li , Huili Tong

引用次数: 0

Abstract

Epidermal Growth Factor (EGF) is a multifunctional cytokine that plays an important role in the growth and development of skeletal muscle. In this study, a mouse skeletal muscle post-injury regeneration model and the C2C12 myoblasts cell line were used to elucidate the molecular mechanism by which EGF promotes myoblast proliferation and differentiation and then improves skeletal muscle post-injury regeneration. EGF regulates the activities of p38-MAPK and PI3K/AKT/mTOR signaling pathways through the Epidermal Growth Factor Receptor (EGFR), thereby promoting the proliferation and differentiation of myoblasts. This finding will support the treatment of skeletal muscle injury, which is of great value in resolving muscle health problems such as muscular atrophy and sarcopenia.

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表皮生长因子促进骨骼肌损伤后再生的机制

表皮生长因子（Epidermal Growth Factor， EGF）是一种在骨骼肌生长发育过程中起重要作用的多功能细胞因子。本研究通过小鼠骨骼肌损伤后再生模型和C2C12成肌细胞系，阐明EGF促进成肌细胞增殖分化进而促进骨骼肌损伤后再生的分子机制。EGF通过表皮生长因子受体（Epidermal Growth Factor Receptor， EGFR）调控p38-MAPK和PI3K/AKT/mTOR信号通路的活性，从而促进成肌细胞的增殖分化。这一发现将支持骨骼肌损伤的治疗，对解决肌肉萎缩和肌肉减少等肌肉健康问题具有重要价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.