F. Tornero-Romero , F. Lage-Estébanez , L. Cantero del Olmo , A. Albiñana-Pérez , A. Palacio-Tamarit y C. Arévalo-Cañas
{"title":"Amiloidosis","authors":"F. Tornero-Romero , F. Lage-Estébanez , L. Cantero del Olmo , A. Albiñana-Pérez , A. Palacio-Tamarit y C. Arévalo-Cañas","doi":"10.1016/j.med.2025.04.021","DOIUrl":null,"url":null,"abstract":"<div><div>Amyloidoses represent a group of complex diseases that occur as a consequence of extracellular amyloid deposition in different tissues. The three main types of amyloidoses are secondary amyloidosis (AA), as a consequence of chronic inflammation produced in infectious and inflammatory diseases, mainly affecting the kidney; light-chain amyloidosis (AL), secondary to the production of immunoglobulin chains in hematological diseases, mainly affecting the heart and kidney; and transthyretin amyloidosis (ATTR) in its hereditary or wild-type variant, predominantly affecting the heart and peripheral nervous system. The treatment of AA and AL is that of the underlying disease, while in ATTR, stabilizers, gene silencing drugs, and eliminating drugs are under investigation.</div></div>","PeriodicalId":100912,"journal":{"name":"Medicine - Programa de Formación Médica Continuada Acreditado","volume":"14 31","pages":"Pages 1871-1882"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine - Programa de Formación Médica Continuada Acreditado","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0304541225000940","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Amyloidoses represent a group of complex diseases that occur as a consequence of extracellular amyloid deposition in different tissues. The three main types of amyloidoses are secondary amyloidosis (AA), as a consequence of chronic inflammation produced in infectious and inflammatory diseases, mainly affecting the kidney; light-chain amyloidosis (AL), secondary to the production of immunoglobulin chains in hematological diseases, mainly affecting the heart and kidney; and transthyretin amyloidosis (ATTR) in its hereditary or wild-type variant, predominantly affecting the heart and peripheral nervous system. The treatment of AA and AL is that of the underlying disease, while in ATTR, stabilizers, gene silencing drugs, and eliminating drugs are under investigation.
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