Total synthesis of D-lyxo- and D-xylo-phytospingosines and fully acylated sphingofungin B

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-04-12 DOI:10.1016/j.tet.2025.134657

Gangarajulu Kesavulu, Kavirayani R. Prasad

引用次数: 0

Abstract

A short synthetic sequence for the synthesis of D-lyxo and D-xylo-phytosphingosine and fully acylated sphingofungin B methyl ester is presented. The key reaction in the synthesis is the addition of lithio tris(methylthio)methane to sulfinimine to install the required chiral amino acid/amino alcohol component.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.