Sex difference in the association between dietary iron intake and bone mineral density in adolescents aged 12–19: A cross-sectional study

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-04-11 DOI:10.1016/j.jtemb.2025.127654

Keyi Li , Jun Han , Jinyu Zhu , Xiang Zhu , Yanfang Zhong , Zefeng Zhu

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引用次数: 0

Abstract

Background

This cross-sectional study investigated the relationship between dietary iron intake and bone mineral density (BMD) in adolescents, exploring how dietary iron intake and other variables collectively influence BMD.

Methods

We analyzed data from participants aged 12–19 years in the National Health and Nutrition Examination Survey (NHANES) conducted from 2005 to 2010. Multivariate linear regression, incorporating multiple covariates, assessed the association between dietary iron intake and BMD at the lumbar and femoral sites. The analysis was stratified by sex, with separate assessments for males and females, and examined the impact of sex on these outcomes, including interactions between dietary iron intake and BMD at both sites.

Results

The study included 2520 adolescents. Dietary iron intake was positively correlated with BMD at the lumbar spine (β = 0.006, 95 % confidence interval [CI] = 0.001–0.011) and femoral regions (β = 0.008, 95 % CI = 0.002–0.013). However, the strength of this association differed significantly by sex. In males, dietary iron intake was positively associated with lumbar (β = 0.006, 95 % CI = 0.001–0.011) and femoral BMD (β = 0.010, 95 % CI = 0.004–0.017). In contrast, no significant correlation was observed between dietary iron intake and BMD at either site in females (P for interaction = 0.005).

Conclusion

Our findings suggest that increased dietary iron intake is associated with higher BMD in adolescent males but not in females.

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12-19岁青少年膳食铁摄入量与骨密度相关性的性别差异：一项横断面研究

本横断面研究探讨了青少年膳食铁摄入量与骨密度（BMD）之间的关系，探讨膳食铁摄入量和其他变量如何共同影响骨密度。方法分析2005 ~ 2010年全国健康与营养调查（NHANES）中12 ~ 19岁的参与者的数据。多元线性回归，结合多个协变量，评估了膳食铁摄入量与腰椎和股骨部位骨密度之间的关系。分析按性别分层，分别对男性和女性进行评估，并检查性别对这些结果的影响，包括两个地点的膳食铁摄入量和骨密度之间的相互作用。结果共纳入2520名青少年。膳食铁摄入量与腰椎骨密度（β = 0.006, 95 %可信区间[CI] = 0.001-0.011）和股骨区域骨密度（β = 0.008, 95 % CI = 0.002-0.013）呈正相关。然而，这种联系的强度因性别而异。在男性中，膳食铁摄入量与腰椎（β = 0.006, 95 % CI = 0.001-0.011）和股骨骨密度（β = 0.010, 95 % CI = 0.004-0.017）呈正相关。相比之下，膳食铁摄入量与女性任一部位的骨密度均无显著相关性（相互作用P = 0.005）。结论：我们的研究结果表明，膳食铁摄入量的增加与青春期男性较高的骨密度有关，而与女性无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.