Exceptional Near-Infrared II Organic Small Molecule Nanoagent for Photoacoustic/Photothermal Imaging-Guided Highly Efficient Therapy in Cancer

IF 4 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Pub Date : 2025-03-12 DOI:10.1021/acs.bioconjchem.5c0005810.1021/acs.bioconjchem.5c00058

Yidong Bin, Lixian Huang, Jiangke Qin, Shulin Zhao*, Jianniao Tian and Liangliang Zhang*,

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Abstract

Near-infrared II (NIR-II) photoacoustic (PA)/photothermal imaging-guided tumor therapy holds great promise in precision medicine for cancer treatment. This work reports on the synthesis and application of an organic small molecule nanoagent that has exceptional PA and photothermal properties in the near-infrared region. BCy-TPE was constructed by linking an NIR-II absorbing cyanine dye BCy-Cl with a twisted tetraphenylethene unit. The synthesized BCy-TPE exhibited an intense absorption peak at 1032 nm. After encapsulation into water-dispersible nanoparticles (NPs), BCy-TPE NPs exhibited two absorption peaks at 880 and 1046 nm. Notably, under 1064 nm laser excitation, BCy-TPE NPs deliver a remarkable photothermal conversion efficiency of 92%, together with superior biocompatibility, photostability, and PA/photothermal imaging capability. Moreover, after intravenous administration of BCy-TPE NPs into 4T1 tumor-bearing mice and treatment with safe-intensity (1.0 W cm^–2 and 1064 nm) laser irradiation, tumor temperature increased rapidly to 52 °C within 1 min and tumors are completely ablated after a single photothermal therapy treatment. Overall, this work offers a novel strategy to develop superb NIR-II photothermal agents for PA/photothermal imaging-guided highly efficient therapy in cancer.

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用于光声/光热成像引导的癌症高效治疗的特殊近红外II有机小分子纳米剂

近红外 II（NIR-II）光声（PA）/光热成像引导的肿瘤治疗在癌症治疗的精准医学中大有可为。本研究报告了一种有机小分子纳米试剂的合成和应用，该试剂在近红外区域具有优异的 PA 和光热特性。BCy-TPE 是通过将吸收近红外-II 波段的氰基染料 BCy-Cl 与扭曲的四苯基乙烯单元连接而构建的。合成的 BCy-TPE 在 1032 纳米波长处显示出强烈的吸收峰。在封装成水可分散纳米粒子（NPs）后，BCy-TPE NPs 在 880 和 1046 纳米波长处显示出两个吸收峰。值得注意的是，在 1064 纳米激光激发下，BCy-TPE NPs 的光热转换效率高达 92%，同时还具有优异的生物相容性、光稳定性和 PA/光热成像能力。此外，给 4T1 肿瘤小鼠静脉注射 BCy-TPE NPs 并用安全强度（1.0 W cm-2 和 1064 nm）的激光照射治疗后，肿瘤温度在 1 分钟内迅速升高至 52 °C，并且在单次光热治疗后肿瘤就被完全消融。总之，这项工作为开发用于 PA/光热成像引导的高效癌症治疗的超强 NIR-II 光热制剂提供了一种新策略。

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来源期刊

Bioconjugate Chemistry 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.