Phototheranostic Zinc Porphyrin Nanoparticles Triggered by an 808 nm Laser: NIR-II Fluorescence/Photoacoustic Imaging-Guided Combined Photothermal/Photodynamic/NO Therapy

IF 4 2区 化学 Q1 BIOCHEMICAL RESEARCH METHODS
Hongyu Chen, Xiaobo Zhao*, Akbar Halimov, Mingkai Fu, Jing Tu, Hui Liu, Huajun Xu* and Jun Liu*, 
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引用次数: 0

Abstract

Single-wavelength lasers that trigger intelligently designed multifunctional theranostic nanoplatforms are urgently needed for early cancer diagnosis and imaging-guided therapy. In this study, a novel zinc porphyrin, Por-TR, was fabricated by incorporating thiophene as a donor and introducing electron acceptors on both sides to expand the conjugation. The presence of multiple flexible chains in the molecular structure of Por-TR inhibits π–π stacking, which allows it to form J nanoaggregates when coassembled with DSPE-PEG2000, demonstrating maximum absorption at approximately 808 nm. These Por-TR NPs provide NIR-II fluorescence/PA dual-modal signals for imaging and serve as a combined PTT/PDT therapeutic agent, making them a suitable multifunctional theranostic nanoplatform. To further improve their therapeutic effects, we embedded a thermosensitive NO donor, BNN6, in the Por-TR nanosystem to achieve combined PDT/PTT/NO therapy. Intravenous injection of Por-TR-NO NPs into 4T1 tumor-bearing mice enabled the accurate observation of tumor location via NIR-II fluorescence/PA dual-modal imaging. In vivo therapy results show that the Por-TR-NO NPs exhibited remarkable antitumor efficacy in combined PTT/PDT/NO therapy, which was triggered by an 808 nm laser. Overall, this nanoplatform offers a versatile approach to cancer diagnosis and treatment.

Abstract Image

808 nm激光触发的光治疗卟啉锌纳米颗粒:NIR-II荧光/光声成像引导的光热/光动力/NO联合治疗
早期癌症诊断和成像引导治疗迫切需要能触发智能设计的多功能治疗纳米平台的单波长激光。本研究通过将噻吩作为供体并在两侧引入电子受体以扩大共轭作用,制备了一种新型锌卟啉 Por-TR。Por-TR 分子结构中存在多条柔性链,抑制了 π-π 堆叠,使其在与 DSPE-PEG2000 共组装时形成 J 纳米聚集体,在约 808 纳米波长处显示出最大吸收。这些 Por-TR NPs 可提供 NIR-II 荧光/PA 双模成像信号,并可作为 PTT/PDT 组合治疗剂,是一种合适的多功能治疗纳米平台。为了进一步提高治疗效果,我们在 Por-TR 纳米系统中嵌入了热敏性 NO 供体 BNN6,以实现 PDT/PTT/NO 联合治疗。将 Por-TR-NO NPs 静脉注射到 4T1 肿瘤小鼠体内,可通过 NIR-II 荧光/PA 双模态成像准确观察肿瘤位置。体内治疗结果表明,Por-TR-NO NPs 在 PTT/PDT/NO 联合治疗中表现出显著的抗肿瘤疗效。总之,这种纳米平台为癌症诊断和治疗提供了一种多功能方法。
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来源期刊
Bioconjugate Chemistry
Bioconjugate Chemistry 生物-化学综合
CiteScore
9.00
自引率
2.10%
发文量
236
审稿时长
1.4 months
期刊介绍: Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.
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