Novel specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil in duplex DNA

IF 3.5 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions Pub Date : 2025-04-15 DOI:10.1039/d5dt00619h

Hidetaka Torigoe, Kei Hirabayashi, Saki Adachi, Jiro Kondo

引用次数: 0

Abstract

Only merury(II) and silver(I) ions specifically bind to natural and naturally modified base pairs in duplex DNA to form metal-mediated base pairs. We found novel specific binding of copper ion to naturally modified base pairs involving 5-fluorouracil(FdU) in duplex DNA to form C–Cu–FdU and FdU–Cu–C.

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铜离子与双链DNA中5-氟尿嘧啶自然修饰碱基对的新型特异性结合

只有汞（II）和银(I)离子特异性地与双链DNA中的天然和自然修饰的碱基对结合，形成金属介导的碱基对。我们发现铜离子与双链DNA中含有5-氟尿嘧啶（FdU）的自然修饰碱基对结合形成C-Cu-FdU和FdU - cu - c。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dalton Transactions 化学-无机化学与核化学

CiteScore

6.60

自引率

7.50%

发文量

1832

审稿时长

1.5 months

期刊介绍： Dalton Transactions is a journal for all areas of inorganic chemistry, which encompasses the organometallic, bioinorganic and materials chemistry of the elements, with applications including synthesis, catalysis, energy conversion/storage, electrical devices and medicine. Dalton Transactions welcomes high-quality, original submissions in all of these areas and more, where the advancement of knowledge in inorganic chemistry is significant.