Deuteration of organic compounds by electrolysis of glucose-heavy water using a graphene oxide membrane reactor

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-04-14 DOI:10.1039/d5cc01646k

Le Mai Hong Tham, Imam Sahroni, Ghina Kifayah Putri, Taiga Kodama, Muhammad Fadil, Takeru Nakahara, Ami Takase, Muhammad Sohail Ahmad, Armando T. Quitain, Yusuke Inomata, Prasert Reubroycharoen, Tetsuya Kida

引用次数: 0

Abstract

This study explores the cost-effective synthesis of deuterium-labelled compounds via electrolysis of glucose-heavy water (D₂O) employing a proton-conducting graphene oxide membrane (GOM) with Pt/C and IrO₂/Al₂O₃. C(sp³)–H bonds of mono, double, and triple methyl groups in aromatic compounds were successfully deuterated with high deuterium incorporation (%) and excellent yield (%).

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利用氧化石墨烯膜反应器电解葡萄糖-重水对有机化合物进行氘化

本研究探讨了通过电解葡萄糖重水（D2O），利用带有 Pt/C 和 IrO2/Al2O3 的质子传导氧化石墨烯膜（GOM），以经济高效的方式合成氘标记化合物。芳香族化合物中的单甲基、双甲基和三甲基的 C（sp3）-H 键被成功氚化，氚掺入率高（%），收率高（%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.