Testosterone, 8-Oxo-2′-Deoxyguanosine (8-OHdG) and Cu/Zn Superoxide Dismutase (SOD) in Adult Shuar Males of Amazonian Ecuador: A Test for Evidence of Trade-Offs Between Reproductive Effort and Oxidative Stress

IF 1.6 4区医学 Q1 ANTHROPOLOGY

American Journal of Human Biology Pub Date : 2025-04-15 DOI:10.1002/ajhb.70042

R. G. Bribiescas, A. Sancilio, D. Amir, T. J. Cepon-Robins, T. Gildner, M. A. Liebert, F. Madimenos, S. S. Urlacher, J. Snodgrass, L. Sugiyama

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引用次数: 0

Abstract

Objectives

Reproductive effort incurs the cost of biological aging and morbidity by compromising somatic maintenance when key resources are limited. Oxidative stress is positively correlated with reproductive effort in adult human females and non-human male animal models, but human males are understudied. We hypothesized that due to its anabolic and metabolic promotion of reproductive effort in human males, testosterone would be positively associated with biomarkers of oxidative stress.

Methods

Urinary testosterone in adult Shuar males of Amazonia Ecuador, a foraging/horticultural population, was measured with urinary 8-hydroxy-2′ -deoxyguanosine (8-OHdG), a biomarker of oxidative stress, and Cu/Zn superoxide dismutase (Cu/Zn SOD), a protective antioxidant against oxidative stress. Age and anthropometric measures were included in multivariate models.

Results

No significant correlation was observed between testosterone and 8-OHdG, r² = 0.01, p = 0.61, n = 29, or Cu/Zn SOD, r² = 0.0005, p = 0.93, n = 17. Multiple linear regression models including testosterone, Cu/Zn SOD, anthropometrics, and age, with 8-OHdG as the dependent variable, were modestly supportive of an association. The most parsimonious 8-OHdG model included age, Cu/Zn SOD, and testosterone (R^{2 adjusted} = 0.38, p = 0.04, AICc = 141.95). All multivariate models for Cu/Zn SOD were not significant (p > 0.05).

Conclusions

Oxidative stress may not be a cost of reproductive effort in this population of adult males; perhaps due to consistently low testosterone levels in non-industrialized populations, differences in the metabolic cost of reproductive effort between males and females (i.e., aerobic metabolism), and/or study limitations based on cross-sectional measures of oxidative stress and testosterone.

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睾酮，8-氧-2 ' -脱氧鸟苷（8-OHdG）和Cu/Zn超氧化物歧化酶（SOD）在亚马逊厄瓜多尔成年Shuar男性：生殖努力和氧化应激之间权衡的证据测试

目标在关键资源有限的情况下，生殖努力会损害躯体维护，从而导致生物衰老和发病。在成年女性和非人类雄性动物模型中，氧化应激与生殖努力呈正相关，但对人类雄性动物的研究不足。我们假设，由于睾酮能促进人类雄性生殖努力的合成代谢，因此睾酮与氧化应激的生物标志物呈正相关。方法对厄瓜多尔亚马孙地区从事饲养/园艺活动的成年舒阿尔男性的尿睾酮与尿液中的氧化应激生物标志物 8-hydroxy-2′ -deoxyguanosine (8-OHdG) 和氧化应激保护性抗氧化剂 Cu/Zn 超氧化物歧化酶 (Cu/Zn SOD) 进行了测定。年龄和人体测量指标被纳入多变量模型。结果在睾酮和 8-OHdG（r2 = 0.01，p = 0.61，n = 29）或 Cu/Zn SOD（r2 = 0.0005，p = 0.93，n = 17）之间未观察到明显的相关性。包括睾酮、Cu/Zn SOD、人体测量和年龄在内的多元线性回归模型以 8-OHdG 为因变量，适度支持两者之间存在关联。最合理的 8-OHdG 模型包括年龄、Cu/Zn SOD 和睾酮（调整后 R2 = 0.38，p = 0.04，AICc = 141.95）。Cu/Zn SOD 的所有多变量模型均不显著（p > 0.05）。结论在这一成年男性群体中，氧化应激可能不是生殖努力的代价；这可能是由于非工业化人口的睾酮水平一直较低，男性和女性生殖努力的代谢代价（即有氧代谢）存在差异，和/或基于氧化应激和睾酮的横断面测量的研究存在局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Human Biology 生物-生物学

CiteScore

4.80

自引率

13.80%

发文量

124

审稿时长

4-8 weeks

期刊介绍： The American Journal of Human Biology is the Official Journal of the Human Biology Association. The American Journal of Human Biology is a bimonthly, peer-reviewed, internationally circulated journal that publishes reports of original research, theoretical articles and timely reviews, and brief communications in the interdisciplinary field of human biology. As the official journal of the Human Biology Association, the Journal also publishes abstracts of research presented at its annual scientific meeting and book reviews relevant to the field. The Journal seeks scholarly manuscripts that address all aspects of human biology, health, and disease, particularly those that stress comparative, developmental, ecological, or evolutionary perspectives. The transdisciplinary areas covered in the Journal include, but are not limited to, epidemiology, genetic variation, population biology and demography, physiology, anatomy, nutrition, growth and aging, physical performance, physical activity and fitness, ecology, and evolution, along with their interactions. The Journal publishes basic, applied, and methodologically oriented research from all areas, including measurement, analytical techniques and strategies, and computer applications in human biology. Like many other biologically oriented disciplines, the field of human biology has undergone considerable growth and diversification in recent years, and the expansion of the aims and scope of the Journal is a reflection of this growth and membership diversification. The Journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscripts of unusual interest.