Fusaripotide, A New Polyketide from the Desert-Derived Fungus Fusarium sp. HM84-3

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-03-27 DOI:10.1007/s10600-025-04637-y

Feng-Xiao Wang, Ya-Hui Zhang, Jun Zhang, Zhuang Li, Du-Qiang Luo

引用次数: 0

Abstract

A new polyketide, namely fusaripotide (1), and five known compounds (2–6) were isolated from the desert-derived fungus Fusarium sp. HM84-3. Their structures were determined by detailed analysis of 1D and 2D NMR and MS data. All the isolates were evaluated for their cytotoxicity and anti-inflammatory activities. Compound 2 displayed obvious inhibitory activity against human gastric cancer cells (MGC-803) with an IC₅₀ value of 10.38 μg/mL. Compounds 4–6 showed different degrees of anti-inflammatory activity at the concentration of 10 μg/mL with an inhibition rate range of 51.2–57.0%.

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沙漠源真菌镰刀菌HM84-3的一种新聚酮

从沙漠源真菌Fusarium sp. HM84-3中分离到一个新的聚酮化合物fusaripotide(1)和5个已知化合物（2-6）。通过详细分析一维和二维核磁共振和质谱数据确定了它们的结构。对所有分离株进行了细胞毒性和抗炎活性评价。化合物2对人胃癌细胞（MGC-803）具有明显的抑制活性，IC50值为10.38 μg/mL。化合物4 ~ 6在10 μg/mL浓度下均表现出不同程度的抗炎活性，抑制率范围为51.2 ~ 57.0%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.