Anti-Inflammatory and Antioxidant Constituents from Cuscuta japonica var. formosana

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI:10.1007/s10600-025-04639-w

Li-Chai Chen, Chien-Ming Huang, Zih-Rong Chen, Chia-Ching Liaw, Ming-Jen Cheng, Jen-Wen Hsiao, Jih-Jung Chen

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Abstract

A new amide derivative, cuscujaponamide (1), has been isolated from the aerial parts of Cuscuta japonica var. formosana, together with eight known compounds, kaempferol (2), quercetin (3), astragalin (4), hyperoside (5), (+)-pinoresinol (6), (+)-sesamin (7), caffeic acid (8), and p-coumaric acid (9). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, cuscujaponamide (1), kaempferol (2), hyperoside (5), and (+)-pinoresinol (6) showed potent inhibition with IC₅₀ values of 16.03 ±1.46, 18.52 ± 1.70, 18.17 ± 1.64, and 15.90 ± 2.04 μM, respectively, against LPS-induced NO generation. In addition, compounds 1, 2, 3, and 5 also showed potent DPPH radicals scavenging activities with IC₅₀ values of 17.29 ± 1.63, 19.02 ± 2.14, 15.62 ±1.42, and 13.25 ±1.45 μM, respectively.

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台湾菟丝子抗炎及抗氧化成分研究

从台湾Cuscuta japonica var. formosana的地上部分分离到一种新的酰胺衍生物cuscujaponamide(1)，并分离到山奈酚(2)、槲皮素(3)、黄芪甲苷(4)、金丝桃苷(5)、(+)-松脂醇(6)、(+)-芝麻素(7)、咖啡酸(8)和对香豆酸(9)等8个已知化合物。其中，菟丝子酰胺(1)、山奈酚(2)、金丝桃苷(5)和(+)-松脂醇(6)对lps诱导的NO生成具有较强的抑制作用，IC50值分别为16.03±1.46、18.52±1.70、18.17±1.64和15.90±2.04 μM。此外，化合物1、2、3和5也具有较强的DPPH自由基清除能力，IC50值分别为17.29±1.63 μM、19.02±2.14 μM、15.62±1.42 μM和13.25±1.45 μM。

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.