Adults on the autism spectrum differ from neurotypical peers when self-generating but not passively-experiencing somatosensation: a high-density electrophysiological (EEG) mapping and virtual reality study

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-04-12 DOI:10.1016/j.neuroimage.2025.121215

Emily L. Isenstein , Edward G. Freedman , Grace A. Rico , Zakilya Brown , Duje Tadin , John J. Foxe

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Abstract

Little is known about how different features of tactile inputs affect somatosensory perception in autism. In this study we combined high-density electroencephalography (EEG) and virtual reality (VR) to assess how the volition and pattern consistency of somatosensory stimulation influenced the electrophysiological responses in neurotypical (n = 30) and autistic (n = 30) adults. Specifically, we compared N1 and P300 amplitudes when vibrotactile stimulation were actively triggered by self-motion (Active) versus passively triggered by target-motion (Passive). We also measured the mismatch negativity (MMN) to assess how deviations in the pattern of stimulus duration affected the electrophysiological responses. We observed comparable responses regardless of pattern deviation in the MMN time window between groups, but different patterns of amplitude in this time frame based on whether the stimulation was Active or Passive. In the autism group we observed smaller N1 amplitudes in response to Passive, but not Active, vibrations as compared to the control group. Conversely, there were overall larger magnitude P300 amplitudes in the autism group, but comparable levels of Passive-to-Active attenuation between groups. Overall, the autism cohort demonstrated variation from the neurotypical cohort with respect to the volition of the stimuli, but there were comparable results between groups in response to pattern deviation. These findings suggest that there are subtle differences in how adults with and without autism handle self-generated and externally-generated somatosensory sensations.

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自闭症谱系的成年人在自我产生而非被动体验体感时不同于神经正常的同龄人：一项高密度电生理（EEG）映射和虚拟现实研究

对于触觉输入的不同特征如何影响自闭症的体感知觉，我们知之甚少。在这项研究中，我们结合高密度脑电图（EEG）和虚拟现实（VR）来评估体感刺激的意志和模式一致性如何影响神经正常（n = 30）和自闭症（n = 30）成年人的电生理反应。具体来说，我们比较了由自我运动（Active）主动触发振动触觉刺激和由目标运动（Passive）被动触发振动触觉刺激时的N1和P300振幅。我们还测量了错配负性（MMN），以评估刺激持续时间模式的偏差如何影响电生理反应。无论两组间MMN时间窗的模式偏差如何，我们都观察到可比性的反应，但在这个时间框架内，基于刺激是主动还是被动，振幅模式不同。在自闭症组中，我们观察到被动振动的N1振幅比对照组小，而不是主动振动。相反，自闭症组的P300振幅总体上更大，但两组之间的被动到主动衰减水平相当。总的来说，自闭症组在刺激的意愿方面表现出与神经正常组的差异，但在对模式偏差的反应方面，两组之间的结果具有可比性。这些发现表明，患有自闭症和没有自闭症的成年人在处理自我产生的和外部产生的躯体感觉方面存在细微的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.