Pterostilbene and resveratrol: Exploring their protective mechanisms against skin photoaging – A scoping review

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-04-15 DOI:10.1016/j.bbrep.2025.102011

Raveena Vaidheswary Muralitharan , Siti Fathiah Masre , Dayang Fredalina Basri , Ahmad Rohi Ghazali

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Abstract

Prolonged ultraviolet (UV) exposure depletes the skin's endogenous antioxidants, leading to photoaging. Exogenous antioxidants are essential to counter this, with stilbenes such as pterostilbene and resveratrol emerging as promising candidates due to their antioxidant, anti-inflammatory and anti-cancer properties. The current scoping review presents an overview of the evidence on the effects of pterostilbene and resveratrol on skin photoaging. A literature search was conducted using PubMed, Scopus, and Web of Science databases in April 2025. Original research articles that investigated the effects of pterostilbene and resveratrol on skin photoaging in cells, animals, or humans were included. 9 eligible articles were included in this review. The findings suggest that resveratrol significantly improves skin photoaging, while preliminary evidence indicates that pterostilbene may offer advantages over resveratrol. However, due to the limited research on pterostilbene, further studies are required to confirm its efficacy. Key considerations in establishing valid in vitro and in vivo models, alongside macroscopic and histologic features of photoaging, were also discussed. In conclusion, while resveratrol shows significant promise in combating skin photoaging, pterostilbene is still in the early exploration phases. Advancing to human trials is crucial to confirm the efficacy of these stilbenes in preventing and treating photoaging.

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紫檀芪和白藜芦醇：探讨其对皮肤光老化的保护机制

长期紫外线（UV）照射会消耗皮肤的内源性抗氧化剂，导致光老化。而紫檀芪和白藜芦醇等二苯乙烯类化合物因其抗氧化、抗炎和抗癌特性而成为有前景的候选物质。本范围综述概述了紫檀芪和白藜芦醇对皮肤光老化影响的证据。2025 年 4 月，我们使用 PubMed、Scopus 和 Web of Science 数据库进行了文献检索。研究紫檀芪和白藜芦醇对细胞、动物或人体皮肤光老化影响的原创性研究文章被纳入其中。本综述共纳入 9 篇符合条件的文章。研究结果表明，白藜芦醇能明显改善皮肤光老化，而初步证据表明紫檀素可能比白藜芦醇更有优势。不过，由于对紫檀芪的研究有限，还需要进一步的研究来确认其功效。此外，还讨论了建立有效的体外和体内模型的关键因素，以及光老化的宏观和组织学特征。总之，白藜芦醇在对抗皮肤光老化方面大有可为，而紫檀芪仍处于早期探索阶段。要确认这些二苯乙烯类化合物在预防和治疗光老化方面的功效，推进人体试验至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.