Hydroxyapatite microspheres encapsulated within hybrid hydrogel promote skin regeneration through the activation of Calcium Signaling and Motor Protein pathway

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-04-14 DOI:10.1016/j.bioactmat.2025.04.002

Shuo Liu , Lu Song , Shuwen Huang , Zhanhong Liu , Yang Xu , Zhiyuan Wang , He Qiu , Jing Wang , Zhiru Chen , Yumei Xiao , Hang Wang , Xiangdong Zhu , Kai Zhang , Xingdong Zhang , Hai Lin

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引用次数: 0

Abstract

Hydroxyapatite (HAp), traditionally recognized for its efficacy in bone regeneration, has rarely been explored for skin regeneration applications. This investigation explored HAp microspheres with distinct physicochemical properties tailored away from conventional bone regeneration parameters, and the capacity promoting skin regeneration and mitigating the aging process were investigated when encapsulated in hyaluronate hydrogels. By benchmarking against well-established dermal fillers like PMMA and PLLA, it was revealed the specific attributes of HAp that were conducive to skin regeneration, providing initial insights into the underlying mechanism. HAp enhanced the fibroblast functionality by triggering minimal adaptive immune responses and enhancing the Calcium Signaling and Motor Protein Signaling pathways. This modulation supported the production of normal collagen fibers, essential for ECM maturation and skin structural integrity. The significant ECM regeneration and remodeling capabilities exhibited by the HAp-encapsulated hybrid hydrogels suggested promising application in facial rejuvenation procedures, potentially making a breakthrough in aesthetic and reconstructive surgery.

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封装在混合水凝胶中的羟基磷灰石微球通过激活钙信号和运动蛋白途径促进皮肤再生

羟基磷灰石（HAp）传统上被认为具有骨再生的功效，但很少被用于皮肤再生的应用。本研究探索了不同于传统骨再生参数的HAp微球具有不同的物理化学特性，并研究了透明质酸水凝胶封装后促进皮肤再生和减缓衰老过程的能力。通过对PMMA和PLLA等成熟的真皮填充剂进行基准测试，揭示了HAp有利于皮肤再生的特定属性，为潜在机制提供了初步见解。HAp通过触发最小的适应性免疫反应和增强钙信号和运动蛋白信号通路来增强成纤维细胞的功能。这种调节支持正常胶原纤维的产生，对ECM成熟和皮肤结构完整性至关重要。hap包封的混合水凝胶具有显著的ECM再生和重塑能力，在面部年轻化手术中有很好的应用前景，可能在美容和重建手术中取得突破。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.