Association between long-term benzene exposure and inflammatory bowel disease in a national cohort: The modifying effect of genetic susceptibility

IF 6.2 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2025-04-15 DOI:10.1016/j.ecoenv.2025.118198

Zhi-Hao Xiao , Shaoni Huang , Kai Zhao , Xiaoqin Zhang , Zhi Li , Runze Li , Min Yao , Shaojun Li , Cheng Xu

{"title":"Association between long-term benzene exposure and inflammatory bowel disease in a national cohort: The modifying effect of genetic susceptibility","authors":"Zhi-Hao Xiao , Shaoni Huang , Kai Zhao , Xiaoqin Zhang , Zhi Li , Runze Li , Min Yao , Shaojun Li , Cheng Xu","doi":"10.1016/j.ecoenv.2025.118198","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the effects of environmental benzene exposure and its interaction with genetic susceptibility on inflammatory bowel disease (IBD), with a specific focus on ulcerative colitis (UC) and Crohn's disease (CD).</div></div><div><h3>Methods</h3><div>A total of 432,727 participants from the UK Biobank who were free of IBD at baseline were included in the analysis. The annual average benzene concentrations during the follow-up period were evaluated by air dispersion models. The study assessed the incidence of IBD in relation to ambient benzene exposure using Cox proportional hazard models and estimated the exposure<img>response relationships using restricted cubic spline models. Additive interactions included relative excess risk due to interaction (RERI) and the attributable proportion (AP) to evaluate the interaction between ambient benzene exposure and genetic predisposition.</div></div><div><h3>Results</h3><div>A significant association was identified between ambient benzene exposure and the incidence of IBD, with hazard ratios (95 % confidence intervals) of 1.06 (1.03, 1.09) for IBD, 1.08 (1.04, 1.12) for UC, and 1.03 (0.98, 1.09) for CD per 0.1 μg/m<sup>3</sup> increase. Furthermore, genetic predispositions were found to significantly modify the relationship between ambient benzene exposure and IBD risk. Individuals with the highest genetic risk and benzene exposure had the highest risk of UC.</div></div><div><h3>Conclusion</h3><div>This study provides compelling evidence of the interaction between environmental factors and genetic susceptibility in the pathogenesis of UC. These findings underscore the importance of considering both genetic and environmental influences in future prevention and intervention strategies for IBD.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"296 ","pages":"Article 118198"},"PeriodicalIF":6.2000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ecotoxicology and Environmental Safety","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0147651325005342","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

This study aimed to investigate the effects of environmental benzene exposure and its interaction with genetic susceptibility on inflammatory bowel disease (IBD), with a specific focus on ulcerative colitis (UC) and Crohn's disease (CD).

Methods

A total of 432,727 participants from the UK Biobank who were free of IBD at baseline were included in the analysis. The annual average benzene concentrations during the follow-up period were evaluated by air dispersion models. The study assessed the incidence of IBD in relation to ambient benzene exposure using Cox proportional hazard models and estimated the exposureresponse relationships using restricted cubic spline models. Additive interactions included relative excess risk due to interaction (RERI) and the attributable proportion (AP) to evaluate the interaction between ambient benzene exposure and genetic predisposition.

Results

A significant association was identified between ambient benzene exposure and the incidence of IBD, with hazard ratios (95 % confidence intervals) of 1.06 (1.03, 1.09) for IBD, 1.08 (1.04, 1.12) for UC, and 1.03 (0.98, 1.09) for CD per 0.1 μg/m³ increase. Furthermore, genetic predispositions were found to significantly modify the relationship between ambient benzene exposure and IBD risk. Individuals with the highest genetic risk and benzene exposure had the highest risk of UC.

Conclusion

This study provides compelling evidence of the interaction between environmental factors and genetic susceptibility in the pathogenesis of UC. These findings underscore the importance of considering both genetic and environmental influences in future prevention and intervention strategies for IBD.

查看原文本刊更多论文

在一个国家队列中，长期苯暴露与炎症性肠病之间的关系：遗传易感性的修饰作用

本研究旨在探讨环境苯暴露及其与遗传易感性的相互作用对炎症性肠病（IBD）的影响，特别关注溃疡性结肠炎（UC）和克罗恩病（CD）。方法来自UK Biobank的432,727名基线时无IBD的参与者被纳入分析。通过空气扩散模型对随访期间的年平均苯浓度进行了评估。该研究使用Cox比例风险模型评估了IBD发病率与环境苯暴露的关系，并使用限制三次样条模型估计了暴露-反应关系。加性相互作用包括相互作用的相对过量风险（rei）和可归因比例（AP），用于评价环境苯暴露与遗传易感性之间的相互作用。结果环境苯暴露与IBD发病率呈显著相关，每增加0.1 μg/m3， IBD的风险比为1.06 (1.03,1.09)，UC的风险比为1.08 (1.04,1.12)，CD的风险比为1.03(0.98,1.09)，可信区间为95 %。此外，发现遗传倾向显著改变了环境苯暴露与IBD风险之间的关系。具有最高遗传风险和苯暴露的个体患UC的风险最高。结论本研究为UC发病过程中环境因素与遗传易感性的相互作用提供了有力证据。这些发现强调了在未来IBD的预防和干预策略中考虑遗传和环境影响的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.