Engineering endothelialized small-diameter artificial blood vessels: Strategies, advances and applications

IF 12.7 1区材料科学 Q1 ENGINEERING, MULTIDISCIPLINARY

Composites Part B: Engineering Pub Date : 2025-04-09 DOI:10.1016/j.compositesb.2025.112505

Yijia Guo , Huersan Wusiman , Liqin Zhao , Oscar senanu James-ocloo , Xin Han , Yekai Miao , Jing Nie , Lei Wang , Jingjing Du , Yan Wei , Xiaojie Lian , Xudong Ma , Di Huang

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引用次数: 0

Abstract

Due to the lack of suitable autologous grafts and complications such as infection, thrombosis, and intimal hyperplasia associated with synthetic grafts, small-diameter artificial blood vessels (Inner diameter < 6 mm) currently used in the treatment of cardiovascular diseases often fail in clinical applications. Rapid vascular endothelialization has been identified as an effective strategy for promoting long-term patency and preventing thrombosis in artificial blood vessels. This review summarizes recent advances in biofabrication technologies and materials for artificial vascular grafts, along with strategies for achieving rapid endothelialization. These strategies include in vitro co-culture with cells, activation of adhesive sites on material surfaces, incorporation of bioactive molecules, and modifications to the inner wall structure of artificial blood vessels. Additionally, the clinical applications and research progress related to small-diameter artificial blood vessels are discussed, providing a perspective on their potential future impact.

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内皮化小直径人造血管工程：策略、进展和应用

由于缺乏合适的自体移植物以及人工移植物相关的感染、血栓形成和内膜增生等并发症，小直径人工血管(内径<；6毫米)目前用于治疗心血管疾病，在临床应用中往往失败。快速血管内皮化被认为是促进人工血管长期通畅和预防血栓形成的有效策略。本文综述了人工血管移植生物制造技术和材料的最新进展，以及实现快速内皮化的策略。这些策略包括与细胞体外共培养，激活材料表面的粘附位点，结合生物活性分子，以及修改人工血管的内壁结构。此外，本文还讨论了小直径人工血管的临床应用和研究进展，并对其未来的潜在影响进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Composites Part B: Engineering 工程技术-材料科学：复合

CiteScore

24.40

自引率

11.50%

发文量

784

审稿时长

21 days

期刊介绍： Composites Part B: Engineering is a journal that publishes impactful research of high quality on composite materials. This research is supported by fundamental mechanics and materials science and engineering approaches. The targeted research can cover a wide range of length scales, ranging from nano to micro and meso, and even to the full product and structure level. The journal specifically focuses on engineering applications that involve high performance composites. These applications can range from low volume and high cost to high volume and low cost composite development. The main goal of the journal is to provide a platform for the prompt publication of original and high quality research. The emphasis is on design, development, modeling, validation, and manufacturing of engineering details and concepts. The journal welcomes both basic research papers and proposals for review articles. Authors are encouraged to address challenges across various application areas. These areas include, but are not limited to, aerospace, automotive, and other surface transportation. The journal also covers energy-related applications, with a focus on renewable energy. Other application areas include infrastructure, off-shore and maritime projects, health care technology, and recreational products.