Brunodelphinone and Brunodelphinine a, two novel C20-diterpenoid alkaloids isolated from Delphinium brunonianum Royle

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-04-14 DOI:10.1016/j.fitote.2025.106532

Yuan-sheng Zou , Ze-ren Dawa , Fang-le Liu , Mei-qi Wang , Chen-chen Zhu , Chao-zhan Lin

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引用次数: 0

Abstract

A novel htisine-type C₂₀-diterpene alkaloid with a benzoate skeleton Brunodelphinone (1), a novel htisine-type C₂₀-diterpenoid alkaloid Brunodelphinine A (2), along with seven known diterpenoid alkaloids (3–9), four aporphinoid alkaloids (10−13), one β-Carboline alkaloid (14), and four flavonoid glycosides (15–18), were isolated from Delphinium brunonianum Royle. Their structures were elucidated by extensive spectroscopic analyses (including 1D and 2D-NMR, HR-ESI-MS, and single-crystal X-ray diffraction analyses). The lipid-lowering and anti-inflammatory activities of compounds were evaluated using the FFA-induced lipid accumulation in mouse primary hepatocytes (MPHs). Compound 2 significantly alleviated the FFA-induced lipid accumulation and suppressed the levels of ALT, TNF-α, and IL-6 in MPHs.

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从 Delphinium brunonianum Royle 分离出的两种新型 C20-二萜生物碱 Brunodelphinone 和 Brunodelphinine a

从褐飞虱中分离得到一种新型组氨酸型c20 -二萜生物碱(1)、一种新型组氨酸型c20 -二萜生物碱Brunodelphinone(2)，以及7种已知的二萜生物碱（3-9）、4种aporphinoid生物碱（10−13）、1种β-Carboline生物碱（14）和4种黄酮类苷（15-18）。通过广泛的光谱分析（包括1D和2D-NMR， HR-ESI-MS和单晶x射线衍射分析）阐明了它们的结构。通过脂肪酸诱导小鼠原代肝细胞（MPHs）脂质积累，评价化合物的降脂和抗炎活性。化合物2可明显减轻fa诱导的脂质积累，抑制心肌细胞中ALT、TNF-α和IL-6的水平。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.