Effect of green synthesized silver nanoparticles using the aqueous extract of Lavandula angustifolia Mill. Against ethanol-induced gastric ulcers in rats

IF 3.4 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biocatalysis and agricultural biotechnology Pub Date : 2025-04-09 DOI:10.1016/j.bcab.2025.103584

Maryam Moradi , Parichehr Hanachi , Seifollah Bahramikia , Mansoureh Tavan

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Abstract

Lavandula angustifolia Mill. (Lamiaceae) possess valuable bioactive compounds such as polyphenols and thus this plant is gaining interest to green synthesis of nanoparticles as source of reducing, stabilizing, and capping agents. ‏Therefore, in the present study, aqueous extract of.

L. angustifolia was used for green synthesis of silver nanoparticles (La-AgNPs). The characterizations of La-AgNPs were determined by UV–Vis spectroscopy, FTIR, XRD, SEM, and EDX. Additionally, the effect of La-AgNPs on gastric damage caused by ethanol in desert rats was investigated. Firstly, Wistar rats were pre-treated with La-AgNPs (5 and 20 mg/kg) and famotidine at (50 mg/kg). Then, an oral dose of ethanol was administered to rats to induce gastric ulcers. The results showed that La-AgNPs had optimal size (69.35 nm) and spherical and cubical shapes. Moreover, the consumption of La-AgNPs orally caused a significant decrease in gastric ulcer index and gastric juice volume, as well as an increase in pH. In addition, tissue nitric oxide (NO), superoxide dismutase, catalase, and glutathione levels increased and serum NO, reactive oxygen species, and malondialdehyde levels decreased in rats pre-treated with La-AgNPs and famotidine drug compared to the ethanol group. The histopathological results confirmed the above cases. This study showed that La-AgNPs can be a promising treatment for gastric ulcer disease caused by ethanol consumption.

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薰衣草水提液对绿色合成纳米银的影响。抗乙醇引起的大鼠胃溃疡

薰衣草。（Lamiaceae）具有宝贵的生物活性化合物，如多酚，因此这种植物对绿色合成纳米颗粒作为还原，稳定和封盖剂的来源越来越感兴趣。因此，在本研究中，l。绿色合成银纳米粒子（La-AgNPs）。采用紫外可见光谱（UV-Vis）、红外光谱（FTIR）、x射线衍射（XRD）、扫描电镜（SEM）和电子能谱（EDX）对La-AgNPs进行表征。此外，还研究了La-AgNPs对荒漠大鼠乙醇致胃损伤的影响。首先，采用La-AgNPs（5、20 mg/kg）和法莫替丁（50 mg/kg）预处理Wistar大鼠。然后，给大鼠口服一定剂量的乙醇诱导胃溃疡。结果表明，La-AgNPs具有最佳尺寸（69.35 nm）、球形和立方形状。此外，与乙醇组相比，口服La-AgNPs可显著降低胃溃疡指数、胃液体积和ph值，并使组织一氧化氮（NO）、超氧化物歧化酶、过氧化氢酶和谷胱甘肽水平升高，血清NO、活性氧和丙二醛水平降低。组织病理学结果证实了上述病例。本研究表明，La-AgNPs可能是一种很有前景的治疗乙醇消耗引起的胃溃疡疾病的方法。

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来源期刊

Biocatalysis and agricultural biotechnology Agricultural and Biological Sciences-Agronomy and Crop Science

CiteScore

7.70

自引率

2.50%

发文量

308

审稿时长

48 days

期刊介绍： Biocatalysis and Agricultural Biotechnology is the official journal of the International Society of Biocatalysis and Agricultural Biotechnology (ISBAB). The journal publishes high quality articles especially in the science and technology of biocatalysis, bioprocesses, agricultural biotechnology, biomedical biotechnology, and, if appropriate, from other related areas of biotechnology. The journal will publish peer-reviewed basic and applied research papers, authoritative reviews, and feature articles. The scope of the journal encompasses the research, industrial, and commercial aspects of biotechnology, including the areas of: biocatalysis; bioprocesses; food and agriculture; genetic engineering; molecular biology; healthcare and pharmaceuticals; biofuels; genomics; nanotechnology; environment and biodiversity; and bioremediation.