Effect of green synthesized silver nanoparticles using the aqueous extract of Lavandula angustifolia Mill. Against ethanol-induced gastric ulcers in rats

IF 3.4 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biocatalysis and agricultural biotechnology Pub Date : 2025-04-09 DOI:10.1016/j.bcab.2025.103584

Maryam Moradi , Parichehr Hanachi , Seifollah Bahramikia , Mansoureh Tavan

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引用次数: 0

Abstract

Lavandula angustifolia Mill. (Lamiaceae) possess valuable bioactive compounds such as polyphenols and thus this plant is gaining interest to green synthesis of nanoparticles as source of reducing, stabilizing, and capping agents. ‏Therefore, in the present study, aqueous extract of.

L. angustifolia was used for green synthesis of silver nanoparticles (La-AgNPs). The characterizations of La-AgNPs were determined by UV–Vis spectroscopy, FTIR, XRD, SEM, and EDX. Additionally, the effect of La-AgNPs on gastric damage caused by ethanol in desert rats was investigated. Firstly, Wistar rats were pre-treated with La-AgNPs (5 and 20 mg/kg) and famotidine at (50 mg/kg). Then, an oral dose of ethanol was administered to rats to induce gastric ulcers. The results showed that La-AgNPs had optimal size (69.35 nm) and spherical and cubical shapes. Moreover, the consumption of La-AgNPs orally caused a significant decrease in gastric ulcer index and gastric juice volume, as well as an increase in pH. In addition, tissue nitric oxide (NO), superoxide dismutase, catalase, and glutathione levels increased and serum NO, reactive oxygen species, and malondialdehyde levels decreased in rats pre-treated with La-AgNPs and famotidine drug compared to the ethanol group. The histopathological results confirmed the above cases. This study showed that La-AgNPs can be a promising treatment for gastric ulcer disease caused by ethanol consumption.

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来源期刊

Biocatalysis and agricultural biotechnology Agricultural and Biological Sciences-Agronomy and Crop Science

CiteScore

7.70

自引率

2.50%

发文量

308

审稿时长

48 days

期刊介绍： Biocatalysis and Agricultural Biotechnology is the official journal of the International Society of Biocatalysis and Agricultural Biotechnology (ISBAB). The journal publishes high quality articles especially in the science and technology of biocatalysis, bioprocesses, agricultural biotechnology, biomedical biotechnology, and, if appropriate, from other related areas of biotechnology. The journal will publish peer-reviewed basic and applied research papers, authoritative reviews, and feature articles. The scope of the journal encompasses the research, industrial, and commercial aspects of biotechnology, including the areas of: biocatalysis; bioprocesses; food and agriculture; genetic engineering; molecular biology; healthcare and pharmaceuticals; biofuels; genomics; nanotechnology; environment and biodiversity; and bioremediation.