Synthesis of Substituted Imidazo[1,2‐a]pyridines, Imidazo[1,2‐a]pyrazines and Imidazo[1,2‐b]pyridazines by Multicomponent Reactions Using Green Solvents

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-07-12 DOI:10.1002/ejoc.202500343

Abdelkarim El Qami , Gatien Messire , Gaëtan Bouchery , Emma Caillet , Sloan Steiner , Sabine Berteina‐Raboin

引用次数: 0

Abstract

Herein, the synthesis of imidazo[1,2‐a]pyridines, imidazo[1,2‐a]pyrazines and imidazo[1,2‐b]pyridazines by a multicomponent Groebke–Blackburn–Bienaymé reaction is described under sustainable conditions using eucalyptol as green solvent. After determining the optimum conditions for catalysis, a library of 32 compounds with activity on the central nervous system was quickly and efficiently assembled.

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绿色溶剂下多组分反应合成取代咪唑[1,2-a]吡啶、咪唑[1,2-a]吡嗪和咪唑[1,2-b]吡嗪

在此，我们介绍了在可持续条件下，以桉叶油醇为绿色溶剂，通过多组分格罗布克-布莱克本-比奈梅（GBB）反应合成咪唑并[1,2-a]吡啶、咪唑并[1,2-a]吡嗪和咪唑并[1,2-b]哒嗪的过程。在确定了最佳催化条件后，我们快速、高效地建立了一个包含 32 种对中枢神经系统具有活性的化合物库。

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.