What Are the Experiences, Views and Perceptions of Patients, Carers and Clinicians of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs)? A Scoping Review

IF 3.2 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Health Expectations Pub Date : 2025-04-14 DOI:10.1111/hex.70251

Sam Febrey, Michael Nunns, Jill Buckland, Rebecca Abbott, Alison Bethel, Rebecca Whear, Kate Boddy, G. J. Melendez-Torres, Jo Thompson Coon, Liz Shaw

{"title":"What Are the Experiences, Views and Perceptions of Patients, Carers and Clinicians of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs)? A Scoping Review","authors":"Sam Febrey, Michael Nunns, Jill Buckland, Rebecca Abbott, Alison Bethel, Rebecca Whear, Kate Boddy, G. J. Melendez-Torres, Jo Thompson Coon, Liz Shaw","doi":"10.1111/hex.70251","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a pharmacological treatment option for both diabetes and weight loss. Qualitative evidence is vital in providing greater understanding of patients, practitioners and carers experience of taking or delivering GLP-1 RAs. This evidence can inform the current or future configuration and delivery of services. We conducted a scoping review to better understand the quantity, nature and key characteristics of qualitative primary evidence which explores the experiences, views and perceptions of patients, carers and clinicians regarding the use of GLP-1 RAs.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Four bibliographic databases were searched on 10 July 2024: MEDLINE, APA PsycInfo via Ovid, CINAHL Ultimate via EBSCOhost, ProQuest Dissertations and Theses Global via ProQuest. We also searched Google Scholar, two clinical trials registries, the pre-print server medRxiv and conducted citation searches. We sought qualitative research about the experiences of patients, carers and practitioners about any aspect of taking or prescribing GLP-1RAs, for any indication. Study selection and data extraction were performed by two independent reviewers. The included studies were collated, and their characteristics were described.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>After de-duplication 1545 titles and abstracts were screened for relevance, with 77 full-text articles assessed for eligibility, resulting in 25 included studies. More studies were focused on type 2 diabetes (<i>n</i> = 12) than weight loss (<i>n</i> = 9) or any indication (<i>n</i> = 4). The experiences of carers were not represented. No one area of experience (e.g. different indications or viewpoints) was well represented, either due to the absence or narrow focus of studies or lack of an in-depth analytical approach.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Whilst primary qualitative evidence exploring patient and clinician experience of GLP-1 RAs was identified in this scoping review, the findings highlight a need for more robust qualitative research to be conducted across all user groups, in particular involving carers, and especially for the indication of weight loss within service settings. This evidence gap needs to be urgently addressed to ensure GLP-1 RAs are appropriately prescribed and patients and carers receive support from services suited to their needs.</p>\n </section>\n \n <section>\n \n <h3> Patient or Public Contribution</h3>\n \n <p>Seventeen public collaborators contributed to the search by suggesting additional search terms, helping define the population for inclusion and contributing to protocol development. Their thoughts on the findings of the review helped form the basis for the discussion of this paper.</p>\n </section>\n </div>","PeriodicalId":55070,"journal":{"name":"Health Expectations","volume":"28 2","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/hex.70251","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health Expectations","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/hex.70251","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a pharmacological treatment option for both diabetes and weight loss. Qualitative evidence is vital in providing greater understanding of patients, practitioners and carers experience of taking or delivering GLP-1 RAs. This evidence can inform the current or future configuration and delivery of services. We conducted a scoping review to better understand the quantity, nature and key characteristics of qualitative primary evidence which explores the experiences, views and perceptions of patients, carers and clinicians regarding the use of GLP-1 RAs.

Methods

Four bibliographic databases were searched on 10 July 2024: MEDLINE, APA PsycInfo via Ovid, CINAHL Ultimate via EBSCOhost, ProQuest Dissertations and Theses Global via ProQuest. We also searched Google Scholar, two clinical trials registries, the pre-print server medRxiv and conducted citation searches. We sought qualitative research about the experiences of patients, carers and practitioners about any aspect of taking or prescribing GLP-1RAs, for any indication. Study selection and data extraction were performed by two independent reviewers. The included studies were collated, and their characteristics were described.

Results

After de-duplication 1545 titles and abstracts were screened for relevance, with 77 full-text articles assessed for eligibility, resulting in 25 included studies. More studies were focused on type 2 diabetes (n = 12) than weight loss (n = 9) or any indication (n = 4). The experiences of carers were not represented. No one area of experience (e.g. different indications or viewpoints) was well represented, either due to the absence or narrow focus of studies or lack of an in-depth analytical approach.

Conclusion

Whilst primary qualitative evidence exploring patient and clinician experience of GLP-1 RAs was identified in this scoping review, the findings highlight a need for more robust qualitative research to be conducted across all user groups, in particular involving carers, and especially for the indication of weight loss within service settings. This evidence gap needs to be urgently addressed to ensure GLP-1 RAs are appropriately prescribed and patients and carers receive support from services suited to their needs.

Patient or Public Contribution

Seventeen public collaborators contributed to the search by suggesting additional search terms, helping define the population for inclusion and contributing to protocol development. Their thoughts on the findings of the review helped form the basis for the discussion of this paper.

Abstract Image

查看原文本刊更多论文

患者、护理人员和临床医生对胰高血糖素样肽-1受体激动剂（GLP-1 RAs）的经验、观点和看法是什么？范围检讨

胰高血糖素样肽-1受体激动剂（GLP-1 RAs）是糖尿病和减肥的一种药物治疗选择。定性证据对于更好地了解患者、从业人员和护理人员服用或递送GLP-1 RAs的经验至关重要。这些证据可以为当前或未来的服务配置和交付提供信息。我们进行了一项范围审查，以更好地了解定性主要证据的数量、性质和关键特征，这些证据探讨了患者、护理人员和临床医生关于使用GLP-1 RAs的经验、观点和看法。方法于2024年7月10日检索MEDLINE、APA PsycInfo（通过Ovid）、CINAHL Ultimate（通过EBSCOhost）、ProQuest Dissertations和Theses Global（通过ProQuest） 4个文献数据库。我们还检索了谷歌Scholar、两个临床试验注册库、预印本服务器medRxiv，并进行了引文检索。我们对患者、护理人员和从业人员关于服用或开GLP-1RAs的任何方面的经验进行了定性研究，以寻找任何适应症。研究选择和数据提取由两名独立评论者完成。对纳入的研究进行整理，并对其特征进行描述。结果在去重复后，1545篇标题和摘要被筛选为相关性，77篇全文文章被评估为合格，最终纳入了25篇研究。更多的研究关注于2型糖尿病（n = 12），而不是减肥（n = 9）或任何适应症（n = 4）。看护人的经历没有被描述出来。没有一个领域的经验（例如，不同的迹象或观点）得到很好的代表，要么是由于缺乏或研究的重点狭窄，要么是缺乏深入的分析方法。结论：虽然在本次范围审查中确定了探索GLP-1 RAs患者和临床医生经验的主要定性证据，但研究结果强调需要在所有用户群体中进行更有力的定性研究，特别是涉及护理人员，特别是在服务环境中减肥的指征。迫切需要解决这一证据差距，以确保GLP-1 RAs得到适当的处方，并确保患者和护理人员得到适合其需求的服务的支持。17位公共合作者通过提出额外的搜索条件，帮助定义纳入的人群，并为方案制定做出贡献，为搜索做出了贡献。他们对审查结果的想法有助于形成本文讨论的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Health Expectations 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.20

自引率

9.40%

发文量

251

审稿时长

>12 weeks

期刊介绍： Health Expectations promotes critical thinking and informed debate about all aspects of patient and public involvement and engagement (PPIE) in health and social care, health policy and health services research including: • Person-centred care and quality improvement • Patients'' participation in decisions about disease prevention and management • Public perceptions of health services • Citizen involvement in health care policy making and priority-setting • Methods for monitoring and evaluating participation • Empowerment and consumerism • Patients'' role in safety and quality • Patient and public role in health services research • Co-production (researchers working with patients and the public) of research, health care and policy Health Expectations is a quarterly, peer-reviewed journal publishing original research, review articles and critical commentaries. It includes papers which clarify concepts, develop theories, and critically analyse and evaluate specific policies and practices. The Journal provides an inter-disciplinary and international forum in which researchers (including PPIE researchers) from a range of backgrounds and expertise can present their work to other researchers, policy-makers, health care professionals, managers, patients and consumer advocates.