The role of semaphorin 3A in the pathogenesis and progression of Alzheimer’s disease and other aging-related diseases: A comprehensive review

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmacological research Pub Date : 2025-04-11 DOI:10.1016/j.phrs.2025.107732

Jiayu Yuan , Rui Huang , Jianfei Nao , Xiaoyu Dong

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引用次数: 0

Abstract

Aging serves as a pivotal factor in the etiology of numerous diseases, such as Alzheimer's disease (AD), Parkinson's disease, diabetes, osteoarthritis, atherosclerosis and aging-related macular degeneration. Notably, these diseases often interact with AD through various pathways, facilitating the onset or progression of one another. Semaphorin 3 A (Sema3A), a protein that is essential for axonal guidance during neural development, has recently been identified as a novel regulator in the pathogenesis and progression of multiple aging-related diseases. This article provides a comprehensive review of the expression patterns and mechanisms of action of Sema3A in these diseases. Specifically, Sema3A influences the occurrence and development of aging-related diseases by participating in oxidative stress, inflammatory responses, apoptosis, and synaptic plasticity. Therefore, therapeutic strategies targeting Sema3A present promising avenues for delaying the progression of aging-related diseases and offer novel insights and strategies for their treatment.

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信号蛋白3A在阿尔茨海默病和其他衰老相关疾病的发病和进展中的作用：综述

衰老是许多疾病的病因学中的关键因素，如阿尔茨海默病（AD）、帕金森病、糖尿病、骨关节炎、动脉粥样硬化和衰老相关性黄斑变性。值得注意的是，这些疾病经常通过各种途径与AD相互作用，促进彼此的发病或进展。Semaphorin 3 A （Sema3A）是一种在神经发育过程中对轴突引导至关重要的蛋白，最近被发现在多种衰老相关疾病的发病和进展中是一种新的调节因子。本文就Sema3A在这些疾病中的表达模式和作用机制进行综述。具体来说，Sema3A通过参与氧化应激、炎症反应、细胞凋亡和突触可塑性，影响衰老相关疾病的发生和发展。因此，针对Sema3A的治疗策略为延缓衰老相关疾病的进展提供了有希望的途径，并为其治疗提供了新的见解和策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.