Association between platelet-to-lymphocyte ratio at admission and short-term mortality in severe burn patients: a meta-analysis

IF 3.2 3区医学 Q2 CRITICAL CARE MEDICINE

Burns Pub Date : 2025-02-27 DOI:10.1016/j.burns.2025.107444

Zhuo Wang , Zhengjun Cui , Peisheng Wang

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引用次数: 0

Abstract

Background

The platelet-to-lymphocyte ratio (PLR) reflects a pro-inflammatory state, which has been related to the severity and poor prognosis in severe burn patients. However, the results of the previous studies were not consistent. This meta-analysis aims to evaluate the relationship between PLR at admission and short-term mortality in severe burn injuries.

Methods

A comprehensive search was conducted in PubMed, Embase, Web of Science, Wanfang, and CNKI for studies published until September 9, 2024. Cohort studies assessing PLR and short-term mortality in severe burn patients were included. Mean difference (MD) for PLR between survivors and nonsurvivors of severe burn, and odds ratios (OR) for short-term mortality (during hospitalization or within 90 days) comparing between patients with a high versus a low PLR at admission were summarized.

Results

Eleven cohort studies with 4,515 patients were included. The analysis revealed that PLR at admission was significantly lower in survivors compared to nonsurvivors (MD: -14.17; 95% confidence interval [CI]: -28.01 to -0.34; p = 0.04). Subgroup analyses showed consistent findings across various demographics, including age, sex, total body surface area affected by burn, proportion of patients with inhalation injury, follow-up duration, and different study quality scores (p for subgroup difference all > 0.05). Furthermore, a high PLR at admission was associated with an increased risk of short-term mortality (OR: 1.37; 95% CI: 1.16 to 1.63; p < 0.001).

Conclusions and recommendations

A high PLR at admission is associated with an increased risk of short-term mortality in severe burn patients.

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来源期刊

Burns 医学-皮肤病学

CiteScore

4.50

自引率

18.50%

发文量

304

审稿时长

72 days

期刊介绍： Burns aims to foster the exchange of information among all engaged in preventing and treating the effects of burns. The journal focuses on clinical, scientific and social aspects of these injuries and covers the prevention of the injury, the epidemiology of such injuries and all aspects of treatment including development of new techniques and technologies and verification of existing ones. Regular features include clinical and scientific papers, state of the art reviews and descriptions of burn-care in practice. Topics covered by Burns include: the effects of smoke on man and animals, their tissues and cells; the responses to and treatment of patients and animals with chemical injuries to the skin; the biological and clinical effects of cold injuries; surgical techniques which are, or may be relevant to the treatment of burned patients during the acute or reconstructive phase following injury; well controlled laboratory studies of the effectiveness of anti-microbial agents on infection and new materials on scarring and healing; inflammatory responses to injury, effectiveness of related agents and other compounds used to modify the physiological and cellular responses to the injury; experimental studies of burns and the outcome of burn wound healing; regenerative medicine concerning the skin.