Comparison of the efficacy of pharmacological interventions for the prevention of delirium: A systematic review and network meta-analysis

IF 2.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Medicina Clinica Pub Date : 2025-04-14 DOI:10.1016/j.medcli.2025.106918

Xiangwu Zhou , Chengguo Yin

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引用次数: 0

Abstract

Background

In recent years, many pharmacological agents for the prevention of delirium have emerged; however, the efficacy of these agents in preventing delirium remains unclear.

Objective

To compare and rank the efficacy of different pharmacological interventions for the prevention of delirium.

Design

A systematic review and network meta-analysis.

Methods

Relevant randomized controlled trials on drug prevention of delirium were extracted from three electronic databases. A network meta-analysis was then conducted to assess the relative efficacy of drug interventions in preventing delirium. The quality of the data was evaluated using the Cochrane Risk of Bias tool.

Results

A total of 80 randomized controlled trials on drug interventions were included in the final analysis. Treatment with dexmedetomidine can prevent delirium.

Conclusion

Dexmedetomidine treatment can prevent delirium and reduce patient suffering. Healthcare professionals should be encouraged to use dexmedetomidine for delirium prevention.

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比较药物干预对预防谵妄的疗效：系统综述和网络荟萃分析

背景近年来，出现了许多预防谵妄的药物，但这些药物在预防谵妄方面的疗效仍不明确。目的比较不同药物干预对预防谵妄的疗效并对其进行排序。然后进行网络荟萃分析，评估药物干预对预防谵妄的相对疗效。结果共有80项关于药物干预的随机对照试验被纳入最终分析。结论使用右美托咪定治疗可预防谵妄。应鼓励医护人员使用右美托咪定预防谵妄。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina Clinica 医学-医学：内科

CiteScore

3.10

自引率

5.10%

发文量

295

审稿时长

22 days

期刊介绍： Medicina Clínica, fundada en 1943, es una publicación quincenal dedicada a la promoción de la investigación y de la práctica clínica entre los especialistas de la medicina interna, así como otras especialidades. Son características fundamentales de esta publicación el rigor científico y metodológico de sus artículos, la actualidad de los temas y, sobre todo, su sentido práctico, buscando siempre que la información sea de la mayor utilidad en la práctica clínica.