Extracellular vesicles as the common denominator among the 7 Rs of radiobiology: From the cellular level to clinical practice

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-04-09 DOI:10.1016/j.bbcan.2025.189315

Júlia Oliveira Dias , Igor Sampaio Fagundes , Mariana de Cássia Bisio , Victoria da Silva Barboza , Alexandre Arthur Jacinto , Wanessa Fernanda Altei

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引用次数: 0

Abstract

Extracellular vesicles (EVs) are lipid-bound particles released by tumor cells and widely explored in cancer development, progression, and treatment response, being considered as valuable components to be explored as biomarkers or cellular targets to modulate the effect of therapies. The mechanisms underlying the production and profile of EVs during radiotherapy (RT) require addressing radiobiological aspects to determine cellular responses to specific radiation doses and fractionation. In this review, we explore the role of EVs in the 7 Rs of radiobiology, known as the molecular basis of a biological tissue response to radiation, supporting EVs as a shared player in all the seven processes. We also highlight the relevance of EVs in the context of liquid biopsy and resistance to immunotherapy, aiming to establish the connection and utility of EVs as tools in contemporary and precision radiotherapy.

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细胞外囊泡是放射生物学 7 R 中的共同点：从细胞水平到临床实践

细胞外囊泡（EVs）是由肿瘤细胞释放的脂质结合颗粒，在癌症的发生、进展和治疗反应中被广泛探索，被认为是有价值的成分，可以作为生物标志物或细胞靶点来调节治疗效果。放射治疗（RT）期间ev产生和分布的机制需要解决放射生物学方面的问题，以确定细胞对特定辐射剂量和分离的反应。在这篇综述中，我们探讨了ev在放射生物学的7个Rs中的作用，这被称为生物组织对辐射反应的分子基础，支持ev在所有7个过程中发挥共同作用。我们还强调了EVs在液体活检和免疫治疗耐药背景下的相关性，旨在建立EVs作为当代和精确放疗工具的联系和效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.