Transcriptomics uncover inhibition of repair and wound healing pathways in Atlantic halibut (Hippoglossus hippoglossus) after crude oil exposure

IF 6.2 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2025-04-14 DOI:10.1016/j.ecoenv.2025.118151

Elin Sørhus , Kai K. Lie , Sonnich Meier , Tomasz Furmanek , Birgitta Norberg , Prescilla Perrichon

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引用次数: 0

Abstract

Accidental oil spills significantly threaten marine ecosystems and fisheries, impacting biodiversity and ecological health. This study examines the downstream transcriptomic responses of Atlantic halibut larvae exposed to crude oil during organogenesis. Findings show concentration-dependent transcriptional abnormalities. Pathway analysis at 10 days post-hatch (dph), 11 days after cessation of oil exposure, indicates downregulation of inflammatory and reparative pathways. By 18 dph, tissue-specific analyses reveal activation of these pathways, especially in head tissues, alongside upregulation of neuronal signaling pathways. This highlights the complex relationship between oil exposure and transcriptional responses, emphasizing recovery mechanisms represented by regulation of inflammatory, repair and wound healing pathways following oil exposure. The activation of repair pathways in surviving larvae suggests compensatory processes to address oil-induced damage. These novel insights enhance understanding of the molecular mechanisms of oil toxicity and the lasting effects on marine organisms.

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转录组学发现原油暴露后大西洋比目鱼（Hippoglossus hippoglossus）的修复和伤口愈合途径受到抑制

意外石油泄漏严重威胁海洋生态系统和渔业，影响生物多样性和生态健康。本研究探讨了大西洋大比目鱼幼虫在器官发生过程中暴露于原油的下游转录组反应。结果显示浓度依赖性转录异常。在孵化后10天（dph），停止油暴露后11天进行通路分析，表明炎症和修复通路下调。到18 dph时，组织特异性分析揭示了这些通路的激活，特别是在头部组织中，同时上调了神经元信号通路。这突出了油暴露与转录反应之间的复杂关系，强调了油暴露后炎症、修复和伤口愈合途径的调节所代表的恢复机制。在存活的幼虫中，修复途径的激活表明补偿过程可以解决石油引起的损伤。这些新颖的见解加强了对石油毒性的分子机制和对海洋生物的持久影响的理解。

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来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.