A double network composite hydrogel with enhanced transdermal delivery by ultrasound for endometrial injury repair and fertility recovery

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-04-14 DOI:10.1016/j.bioactmat.2025.04.007

Xin Zhang , Shufang Wang , Siyu Wang , Zeyi Long , Cong Lu , Jianlin Wang , Lijun Yang , Cancan Yao , Bin He , Xihua Chen , Taifeng Zhuang , Xiangbo Xu , Yufeng Zheng

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Abstract

Endometrial injury and resulting female infertility pose significant clinical challenges due to the notable shortcomings of traditional treatments. Herein, we proposed a double network composite hydrogel, CSMA-RC-Zn-PNS, which forms a physical barrier on damaged tissue through photo-crosslinking while enabling sustained release of the active ingredient PNS. Based on this, we developed a combined strategy to enhance transdermal delivery efficiency using ultrasound cavitation. In vitro experiments demonstrated that CSMA-RC-Zn-PNS exhibits excellent biosafety, biodegradability, and promotes cell proliferation, migration, and tube formation, along with antioxidant and antibacterial properties. In a rat endometrial injury model, the ultrasound cavitation effect was demonstrated to enhance transdermal delivery efficiency, and the ability of CSMA-RC-Zn-PNS to promote endometrial regeneration, anti-fibrosis and fertility restoration was verified. Overall, this strategy combining CSMA-RC-Zn-PNS hydrogel and ultrasound treatment shows promising applications in endometrial regeneration and female reproductive health.

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一种双网状复合水凝胶，增强超声透皮给药，用于子宫内膜损伤修复和生育恢复

由于传统治疗方法的明显缺陷，子宫内膜损伤和由此导致的女性不孕症给临床带来了重大挑战。在此，我们提出了一种双网络复合水凝胶CSMA-RC-Zn-PNS，它通过光交联在受损组织上形成物理屏障，同时使活性成分PNS得以持续释放。基于此，我们开发了一种联合策略来提高超声空化的透皮给药效率。体外实验表明，CSMA-RC-Zn-PNS具有良好的生物安全性和可生物降解性，并能促进细胞增殖、迁移和成管，同时具有抗氧化和抗菌性能。在大鼠子宫内膜损伤模型中，超声空化作用可提高透皮给药效率，并验证CSMA-RC-Zn-PNS促进子宫内膜再生、抗纤维化和生育恢复的能力。综上所述，CSMA-RC-Zn-PNS水凝胶结合超声治疗在子宫内膜再生和女性生殖健康方面具有广阔的应用前景。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.