Recent Advances in Peptide-Functionalized Hydrogels for Bone Tissue Engineering

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2025-04-03 DOI:10.1021/acsbiomaterials.4c0219810.1021/acsbiomaterials.4c02198

Guanrong Li, Yang Luo, Zeming Hu, Zheyuan Shi, Xu Cao, Rong Xu, Yunfeng Mi, Yudong Yao, Haijiao Mao*, Hua Zhang* and Yingchun Zhu*,

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Abstract

Efficient therapeutic approaches for bone regeneration are urgently required to address the significant challenges associated with the repair of large-scale or long-segment bone defects. Peptide-functionalized hydrogels (PFHs) have emerged as important bioactive materials in bone tissue engineering because they produce biomimetic microenvironments enriched with multiple biochemical signals. This review summarizes the key fabrication techniques for PFHs and discusses their diverse applications in different fields. Furthermore, we systematically highlighted the biochemical functionalization of PFHs, which includes basic functions such as cell adhesion, cell recruitment, and osteoinduction; improved functions such as angiogenesis, biomineralization, immune regulation, and hormone regulation; and other functions, including antimicrobial and antitumor effects. Finally, critical biosafety considerations associated with PFHs and perspectives on developing intelligent PFHs are addressed. This review aims to inspire further research on PFHs and accelerate their applications in bone tissue engineering.

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目前迫切需要高效的骨再生治疗方法，以应对与修复大面积或长段骨缺损相关的重大挑战。肽功能化水凝胶（PFHs）可产生富含多种生化信号的仿生微环境，因此已成为骨组织工程中重要的生物活性材料。本综述总结了 PFHs 的关键制造技术，并讨论了它们在不同领域的各种应用。此外，我们还系统地强调了 PFHs 的生化功能化，其中包括细胞粘附、细胞募集和骨诱导等基本功能；血管生成、生物矿化、免疫调节和激素调节等改进功能；以及包括抗菌和抗肿瘤作用在内的其他功能。最后，还讨论了与全氟辛烷磺酸相关的关键生物安全考虑因素以及开发智能全氟辛烷磺酸的前景。本综述旨在激发对 PFHs 的进一步研究，并加速其在骨组织工程中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

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