Sleep deprivation and memory consolidation in rats: A meta-analysis of experimental studies

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-04-10 DOI:10.1016/j.bbr.2025.115591

Cristina Dumitru , Claudia Iuliana Iacob , Florin Zamfirache , Ruxandra Folostina , Beatrice Mihaela Radu

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引用次数: 0

Abstract

Sleep deprivation (SD) continues to be used today to examine the role of sleep across diverse cognitive domains. Extensive research has been conducted to investigate the impact of SD on memory, though findings across studies have been inconsistent. This meta-analysis systematically assessed the effects of SD on memory performance in rats and identified the factors that may moderate these effects. PubMed, PsychInfo, Google scholar, and Scopus databases were used to search for studies. Out of 128 identified studies, 25 studies with 78 reports were included in the final analysis. A random effects meta-analysis was performed, along with subgroup analysis and meta-regression. The results showed that overall, SD has a negative impact on memory in rats. Additionally, sex, memory response type, and number of learning trials for spatial tasks can act as moderators of the relationship between SD and memory. The type of memory task and assessment method used contributed to variability in observed outcomes, with hippocampus-dependent tasks showing the most pronounced memory impairments. The number of learning trials for spatial tasks also moderated the effects, with more trials mitigating the impact of SD. These findings reinforce the role of sleep in memory, particularly for hippocampus-dependent tasks.

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睡眠剥夺与大鼠记忆巩固：实验研究的荟萃分析

睡眠剥夺（SD）至今仍被用于研究睡眠在不同认知领域中的作用。人们进行了广泛的研究来调查SD对记忆的影响，尽管研究结果并不一致。本荟萃分析系统地评估了SD对大鼠记忆表现的影响，并确定了可能缓和这些影响的因素。使用PubMed、PsychInfo、b谷歌scholar和Scopus数据库进行研究检索。在确定的128项研究中，有25项研究和78份报告被纳入最终分析。随机效应荟萃分析，以及亚组分析和元回归。结果表明，总的来说，SD对大鼠的记忆有负面影响。此外，性别、记忆反应类型和空间任务学习试验次数可以作为SD与记忆之间关系的调节因子。记忆任务的类型和使用的评估方法导致了观察结果的可变性，海马依赖性任务显示出最明显的记忆损伤。空间任务学习试验的数量也会缓和这种影响，更多的试验会减轻记忆障碍的影响。这些发现强化了睡眠在记忆中的作用，特别是对于依赖海马体的任务。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.