Histiocytic sarcoma involving multiple abdominal sites: A rare case with KRAS mutation and response to ICE chemotherapy

Q4 Medicine

Radiology Case Reports Pub Date : 2025-04-12 DOI:10.1016/j.radcr.2025.03.045

Shahad Khalid Hussein Hussein MD, Olga Tcacenco MD

引用次数: 0

Abstract

Histiocytic sarcoma (HS) is a rare and aggressive malignant neoplasm from histiocytic cells. This case report describes a 52-year-old male with HS involving multiple abdominal sites, diagnosed through imaging, histopathology, and immunohistochemical analysis, which identified a KRAS mutation. The patient underwent surgical resection followed by 6 cycles of ICE chemotherapy, resulting in significant clinical improvement and reduction of tumor burden. This case highlights the clinical presentation, diagnostic challenges, and potential treatment approach for this rare malignancy.

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组织细胞肉瘤累及腹部多个部位：一例罕见的KRAS突变和对ICE化疗的反应

组织细胞肉瘤（HS）是一种罕见的侵袭性组织细胞恶性肿瘤。本病例报告描述了一名52岁男性HS，涉及多个腹部部位，通过影像学、组织病理学和免疫组织化学分析诊断为KRAS突变。患者行手术切除后进行6个周期的ICE化疗，临床明显改善，肿瘤负担减轻。这个病例强调了这种罕见恶性肿瘤的临床表现、诊断挑战和潜在的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiology Case Reports Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

1.10

自引率

0.00%

发文量

1074

审稿时长

30 days

期刊介绍： The content of this journal is exclusively case reports that feature diagnostic imaging. Categories in which case reports can be placed include the musculoskeletal system, spine, central nervous system, head and neck, cardiovascular, chest, gastrointestinal, genitourinary, multisystem, pediatric, emergency, women''s imaging, oncologic, normal variants, medical devices, foreign bodies, interventional radiology, nuclear medicine, molecular imaging, ultrasonography, imaging artifacts, forensic, anthropological, and medical-legal. Articles must be well-documented and include a review of the appropriate literature.