ECM, integrins, and DDRs: A nexus of cancer progression, therapy, and future directions

IF 4.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology Pub Date : 2025-04-12 DOI:10.1016/j.matbio.2025.04.002

Md Al Azim, Julie S Di Martino

引用次数: 0

Abstract

Collagen is the most abundant protein in mammals, significantly contributing to cancer progression. Cells express two primary well-conserved collagen receptors, integrins and discoidin domain receptors (DDRs), which bind collagen on distinct sites, suggesting that cancer cells must integrate both signals to decide their fate. The crosstalk between integrins and DDRs mediated by collagen binding produces dynamic, integrated signals that control tumor progression, therapeutic resistance, and cancer cell heterogeneity. This review will discuss the dynamic interplay among collagen, integrins, and DDRs in ECM remodeling during cancer progression and these receptors' crosstalk. In addition, we explored current and future directions for ECM receptor-targeted therapies, including nanotechnologies and precision medicine, to improve therapeutic outcomes by establishing a proper balance between integrins and DDRs in cancer.

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ECM、整合素和ddr：癌症进展、治疗和未来方向的关系

胶原蛋白是哺乳动物体内含量最高的蛋白质，对癌症的发展有重要作用。细胞表达两种主要的保存完好的胶原蛋白受体--整合素和盘状结构域受体（DDRs），它们在不同的部位结合胶原蛋白，这表明癌细胞必须整合这两种信号才能决定其命运。由胶原蛋白结合介导的整合素和 DDRs 之间的串扰产生了动态的整合信号，控制着肿瘤的进展、治疗抗性和癌细胞的异质性。本综述将讨论癌症进展过程中 ECM 重塑过程中胶原蛋白、整合素和 DDR 之间的动态相互作用以及这些受体之间的串扰。此外，我们还探讨了 ECM 受体靶向疗法的当前和未来发展方向，包括纳米技术和精准医疗，以便通过在癌症中的整合素和 DDR 之间建立适当的平衡来改善治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Matrix Biology 生物-生化与分子生物学

CiteScore

11.40

自引率

4.30%

发文量

审稿时长

45 days

期刊介绍： Matrix Biology (established in 1980 as Collagen and Related Research) is a cutting-edge journal that is devoted to publishing the latest results in matrix biology research. We welcome articles that reside at the nexus of understanding the cellular and molecular pathophysiology of the extracellular matrix. Matrix Biology focusses on solving elusive questions, opening new avenues of thought and discovery, and challenging longstanding biological paradigms.