Effect of polystyrene nanoplastics on the intestinal histopathology, oxidative stress, and microbiota of Acrossocheilus yunnanensis

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology Pub Date : 2025-04-08 DOI:10.1016/j.aquatox.2025.107359

Zhaolai Guo , Ruisi Yang , Zexiang Hua , Wenyu Long , Qianqian Xiang

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引用次数: 0

Abstract

Even though extensive research exists on the negative impact of nanoplastics on fish, their effect on the microbiota and intestinal health of freshwater fish remains unclear. This study investigated the impact of polystyrene nanoplastics (PS-NPs) on the microbiota, oxidative stress, and intestinal morphology of the Acrossocheilus yunnanensis (A. yunnanensis) freshwater fish species. The findings demonstrated that PS-NPs induced structural changes (e.g., epithelial rupture and microvilli damage) in the intestinal tissue of A. yunnanensis. Meanwhile, they increased the level of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in the intestine, but did not significantly cause changes in the activities of catalase (CAT) and glutathione S-transferase (GST) enzymes. The microbiome results indicated that PS-NPs increased gut microbial community diversity and Proteobacteria abundance while decreasing the Fusobacteriota content. Furthermore, PS-NPs significantly improved multiple microbial functions such as amino acid and lipid transfer and metabolism, as well as energy generation and conversion. Overall, this study revealed that PS-NPs caused oxidative stress and microbiota dysbiosis in A. yunnanensis, possibly causing intestinal epithelial damage. This research elucidates the mechanism underlying PS-NP toxicity to freshwater fish and its subsequent impact.

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聚苯乙烯纳米塑料对云南对虾肠道组织病理学、氧化应激和微生物群的影响

尽管纳米塑料对鱼类的负面影响已经有了广泛的研究，但它们对淡水鱼的微生物群和肠道健康的影响仍不清楚。本文研究了聚苯乙烯纳米塑料（PS-NPs）对云南跨鱼（A. yunnanensis）微生物群、氧化应激和肠道形态的影响。结果表明，PS-NPs可引起云南田鼠肠组织结构改变（如上皮破裂和微绒毛损伤）。同时，它们增加了肠道丙二醛（MDA）水平和超氧化物歧化酶（SOD）活性，但对过氧化氢酶（CAT）和谷胱甘肽s -转移酶（GST）活性的影响不显著。微生物组学结果表明，PS-NPs增加了肠道微生物群落多样性和变形菌群丰度，降低了梭菌群含量。此外，PS-NPs显著改善了多种微生物功能，如氨基酸和脂肪的转移和代谢，以及能量的产生和转化。综上所述，本研究揭示了PS-NPs引起云南田鼠氧化应激和微生物群失调，可能引起肠上皮损伤。本研究阐明了PS-NP对淡水鱼的毒性机制及其后续影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aquatic Toxicology 环境科学-毒理学

CiteScore

7.10

自引率

4.40%

发文量

250

审稿时长

56 days

期刊介绍： Aquatic Toxicology publishes significant contributions that increase the understanding of the impact of harmful substances (including natural and synthetic chemicals) on aquatic organisms and ecosystems. Aquatic Toxicology considers both laboratory and field studies with a focus on marine/ freshwater environments. We strive to attract high quality original scientific papers, critical reviews and expert opinion papers in the following areas: Effects of harmful substances on molecular, cellular, sub-organismal, organismal, population, community, and ecosystem level; Toxic Mechanisms; Genetic disturbances, transgenerational effects, behavioral and adaptive responses; Impacts of harmful substances on structure, function of and services provided by aquatic ecosystems; Mixture toxicity assessment; Statistical approaches to predict exposure to and hazards of contaminants The journal also considers manuscripts in other areas, such as the development of innovative concepts, approaches, and methodologies, which promote the wider application of toxicological datasets to the protection of aquatic environments and inform ecological risk assessments and decision making by relevant authorities.