Biosynthesis of nano-hydroxyapatite from potential probiotic Bacillus amyloliquefaciens and its effect on osteoblastic cells

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2025-04-11 DOI:10.1016/j.matlet.2025.138549

Sabereh Nouri , Giti Emtiazi , Rasoul Roghanian , Songul Ulag , Oguzhan Gunduz

引用次数: 0

Abstract

The eco-friendly synthesis of nano-biomaterials has gained prominence in bone disorder treatment. This study explores the green synthesis of nano-hydroxyapatite using Bacillus amyloliquefaciens and evaluates its biocompatibility and osteogenic potential in MG-63 and MC3T3-E1 cell lines. Characterization confirmed desirable crystallinity and elemental composition. The nanoparticles exhibited no significant toxicity over 21 days, enhancing matrix mineralization and alkaline phosphatase activity (0.44 U/mg in MG-63, 0.55 U/mg in MC3T3-E1). These findings highlight the potential of probiotic-derived nano-Hydroxyapatite for bone tissue engineering and regenerative medicine.

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潜在益生菌解淀粉芽孢杆菌合成纳米羟基磷灰石及其对成骨细胞的影响

生态友好型纳米生物材料的合成在骨疾病治疗中得到了突出的应用。本研究探讨了利用解淀粉芽孢杆菌绿色合成纳米羟基磷灰石，并对其在MG-63和MC3T3-E1细胞系中的生物相容性和成骨潜能进行了评价。表征证实了理想的结晶度和元素组成。在21天内，纳米颗粒没有表现出明显的毒性，但增强了基质矿化和碱性磷酸酶活性（mg -63为0.44 U/mg， MC3T3-E1为0.55 U/mg）。这些发现突出了益生菌衍生的纳米羟基磷灰石在骨组织工程和再生医学中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive