Study on the preparation of La2(CO3)3·4H2O by ultrasonic-assisted dehydration and its phosphate binding effect

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications Pub Date : 2025-04-09 DOI:10.1016/j.inoche.2025.114479

Yujing Wei , Wangting Zhou , Dezhen Chen , Guanglie Lv , Guoqing Zhang

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Abstract

Lanthanum carbonate tetrahydrate (La₂(CO₃)₃·4H₂O), as the most clinically effective drug for treating hyperphosphatemia, faces challenges in production such as complex preparation processes and low phase purity. To address these shortcomings, an efficient and straightforward method was developed for preparing La₂(CO₃)₃·4H₂O in the form of flake-shaped, characterized by its high phase purity, crystallinity, and dispersibility. In this study, sodium bicarbonate and lanthanum chloride were used as starting materials to synthesize lanthanum carbonate octahydrate (La₂(CO₃)₃·8H₂O) under weakly acidic conditions, and ultrasonic technology was employed for its dehydration to prepare the target product, La₂(CO₃)₃·4H₂O, followed by an investigation of its phosphate binding capacity. The results show that subjecting La₂(CO₃)₃·8H₂O to ultrasonic dehydration treatment with an intensity of 60 W/m² in an ethanol solvent can effectively prevent the formation of basic lanthanum carbonate impurities, successfully preparing La₂(CO₃)₃·4H₂O with high phase purity and good crystallinity. In addition, the obtained sample exhibits excellent dispersibility, featuring a lamellar morphology with a particle size of approximately 5 μm. Phosphate binding experiments further demonstrate that the La₂(CO₃)₃·4H₂O prepared by ultrasound possesses superior phosphate binding capacity, able to bind 90 % of phosphate within 120 min. It was clear that the trivalent lanthanum ion combined with phosphate to form lanthanum phosphate and attached to the surface of the La₂(CO₃)₃·4H₂O sheets. The aforementioned research results indicate that the ultrasonic-assisted dehydration method can prepare La₂(CO₃)₃·4H₂O with excellent performance, and La₂(CO₃)₃·4H₂O exhibits outstanding phosphate binding capacity, showing good potential for clinical applications.

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超声辅助脱水法制备La2(CO3)3·4H2O及其磷酸盐结合效果的研究

碳酸镧四水合物（La2(CO3)3-4H2O）是临床上治疗高磷血症最有效的药物，但在生产过程中面临着制备工艺复杂、相纯度低等挑战。针对这些不足，我们开发了一种高效、简便的方法来制备片状的 La2(CO3)3-4H2O，其特点是相纯度高、结晶度高、分散性好。该研究以碳酸氢钠和氯化镧为起始原料，在弱酸性条件下合成八水合碳酸镧（La2(CO3)3-8H2O），并采用超声波脱水技术制备目标产物 La2(CO3)3-4H2O，然后对其磷酸盐结合能力进行了研究。结果表明，在乙醇溶剂中对 La2(CO3)3-8H2O 进行强度为 60 W/m2 的超声脱水处理，可有效防止碱性碳酸镧杂质的形成，成功制备出相纯度高、结晶度好的 La2(CO3)3-4H2O。此外，所获得的样品具有极佳的分散性，呈片状形态，粒径约为 5 μm。磷酸盐结合实验进一步证明，超声制备的 La2(CO3)3-4H2O 具有卓越的磷酸盐结合能力，能在 120 分钟内结合 90% 的磷酸盐。很明显，三价镧离子与磷酸盐结合形成磷酸镧，并附着在 La2(CO3)3-4H2O 片表面。上述研究结果表明，超声波辅助脱水法可以制备出性能优异的La2(CO3)3-4H2O，而且La2(CO3)3-4H2O表现出卓越的磷酸盐结合能力，具有良好的临床应用潜力。

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来源期刊

Inorganic Chemistry Communications 化学-无机化学与核化学

CiteScore

5.50

自引率

7.90%

发文量

1013

审稿时长

53 days

期刊介绍： Launched in January 1998, Inorganic Chemistry Communications is an international journal dedicated to the rapid publication of short communications in the major areas of inorganic, organometallic and supramolecular chemistry. Topics include synthetic and reaction chemistry, kinetics and mechanisms of reactions, bioinorganic chemistry, photochemistry and the use of metal and organometallic compounds in stoichiometric and catalytic synthesis or organic compounds.