Jahn–Teller-Driven Electronic Modulation of Bio-Heterojunction for Wound Regeneration after Postoperative Tumor Resection

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-04-12 DOI:10.1021/acs.nanolett.5c01632

Miaomiao He, Xuyang Yang, Danni Xiang, Yau Kei Chan, Guangfu Yin, Weizhong Yang, Yi Deng

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Abstract

Abundant ·OH, ¹O₂, and ·O₂^– provide an efficient methodology for rapid tumor and bacteria killing, whereas a limitation focuses on the catalytic efficiency. Thus, Jahn–Teller-driven electronic modulation of a bioheterojunction (bioHJ) platform is developed for the remedy in diabetic infectious wound regeneration after postoperative tumor resection. The bioHJ is composed of MoTe₂/MnO₂ and glucose oxidase (GOx). GOx depletes glucose to H₂O₂, which intercepts their glucose metabolism. The H₂O₂ can be further converted into highly lethal ·OH owing to peroxidase-mimetic activity via the Jahn–Teller effect, while GSH can be consumed due to its GPx-mimetic activity. Both of which can be further amplified upon NIR irradiation as NIR-activatable enzyme-mimetic activities. In vivo studies in a subcutaneous tumor model and infectious model authenticate the ability to kill tumor, defeat bacterial infection, and accelerate wound regeneration. This work enlightens a powerful platform for postoperative infectious wound regeneration of tumor resection using an engineered bioHJ.

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jhn - teller驱动的电子调制生物异质结用于肿瘤切除术后创面再生

丰富的·OH， 1O2和·O2 -为快速杀死肿瘤和细菌提供了有效的方法，然而限制集中在催化效率上。因此，jhn - teller驱动的电子调制生物异质结（bioHJ）平台被开发用于治疗糖尿病感染性伤口术后肿瘤切除后的再生。bioHJ由MoTe2/MnO2和葡萄糖氧化酶（GOx）组成。GOx将葡萄糖消耗为H2O2，从而阻断它们的葡萄糖代谢。通过jhn - teller效应，H2O2可以进一步转化为高致死的·OH，而GSH则可以通过其模拟gpx的活性被消耗。这两种酶在近红外照射下都可以进一步扩增为近红外激活的酶活性。在皮下肿瘤模型和感染模型的体内研究证实了其杀死肿瘤、击败细菌感染和加速伤口再生的能力。本研究为肿瘤切除后应用工程生物hj进行感染性创面再生提供了一个强有力的平台。

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.