The association between medication adherence and the risk of different violent behaviors: A cohort study in young patients with severe mental illness

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research Pub Date : 2025-04-01 DOI:10.1016/j.psychres.2025.116481

Xiaolan Yin , Chuanlong Zuo , Ruoxin Fan , Jun Liu , Hu Xiang , Mingjin Huang , Xing Zhao , Xiang Liu , Xianmei Yang , Yuanyuan Liu

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引用次数: 0

Abstract

Background

Whether poor medication adherence increases the risk of violent behaviors in people with severe mental illness (SMI) is a critical public health issue, but it has not yet been explored in a population of young patients with SMI. This study aims to analyze whether low medication adherence increases the risk of violence to others and self-inflicted violence among young patients with SMI.

Methods

Data for this study was obtained from a community-based cohort of patients with SMI from 2006 to 2018 in western China. The association between medication adherence and various violent behaviors was analyzed using a multilevel Cox proportional risk regression model and restricted mean survival time.

Results

A total of 52,917 young patients with SMI were included in this study. The incidences were 15.6 % for the total violence to others and 1.9 % for the total self-inflicted violence in the low medication adherence group, both higher than that in the non-low adherence group. After controlling confounders, low medication adherence increased the risk of total violence to others (HR=1.673, 95 % CI 1.582–1.768), minor nuisance (HR=1.770, 95 % CI 1.670–1.876), violating APS law (HR=1.754, 95 % CI 1.542–1.995), total self-inflicted violence (HR=1.654, 95 % CI 1.423–1.923), non-suicidal self-injury (HR=1.628, 95 % CI 1.362–1.947), and suicide attempt (HR=1.628, 95 % CI 1.322–2.004).

Conclusions

This study found that low medication adherence increased the risk of violent behaviors in young patients with SMI, suggesting the need for future targeted measures to identify and intervene in the risk of various types of violence that may occur in patients.

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来源期刊

Psychiatry Research 医学-精神病学

CiteScore

17.40

自引率

1.80%

发文量

527

审稿时长

57 days

期刊介绍： Psychiatry Research offers swift publication of comprehensive research reports and reviews within the field of psychiatry. The scope of the journal encompasses: Biochemical, physiological, neuroanatomic, genetic, neurocognitive, and psychosocial determinants of psychiatric disorders. Diagnostic assessments of psychiatric disorders. Evaluations that pursue hypotheses about the cause or causes of psychiatric diseases. Evaluations of pharmacologic and non-pharmacologic psychiatric treatments. Basic neuroscience studies related to animal or neurochemical models for psychiatric disorders. Methodological advances, such as instrumentation, clinical scales, and assays directly applicable to psychiatric research.