Biosynthesis of ergothioneine: current state, achievements, and perspectives

IF 3.9 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Applied Microbiology and Biotechnology Pub Date : 2025-04-12 DOI:10.1007/s00253-025-13476-4

Shun Sato, Azusa Saika, Tatsuyuki Koshiyama, Yukihiro Higashiyama, Tokuma Fukuoka, Tomotake Morita

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Abstract

Ergothioneine (EGT) is a derivative of the amino acid L-histidine that is well known for its strong antioxidant properties. Recent studies on the functional characterization of EGT in both in vivo and in vitro systems have demonstrated its potential applications in pharmaceuticals, food, and cosmetics. The growing demand for EGT in novel applications necessitates the development of safe and cost-effective mass production technologies. Consequently, microbial fermentation for EGT biosynthesis has attracted significant attention. This review focuses on the biosynthesis of EGT via microbial fermentation, explores its biosynthetic mechanisms, and summarizes the latest advancements for industrial EGT production using engineered microbial strains.

• Ergothioneine (EGT) is an L-histidine derivative with strong antioxidant property.

• Recent studies have revealed certain groups of microbes produce EGT naturally.

• Superior EGT producers by genetic modification have been created.

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麦角硫因的生物合成：现状、成就与展望

麦角硫因（EGT）是氨基酸l -组氨酸的衍生物，以其强大的抗氧化特性而闻名。最近对EGT在体内和体外系统中的功能表征的研究表明，EGT在制药、食品和化妆品方面具有潜在的应用前景。新型应用对EGT的需求日益增长，要求开发安全、经济高效的大规模生产技术。因此，微生物发酵合成EGT的研究备受关注。本文综述了微生物发酵合成EGT的研究进展，探讨了EGT的生物合成机理，并对利用工程菌株生产EGT的最新进展进行了综述。麦角硫因（EGT）是一种l -组氨酸衍生物，具有很强的抗氧化性能。•最近的研究表明，某些微生物群可以自然产生EGT。•通过基因改造创造了优质EGT生产商。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Microbiology and Biotechnology 工程技术-生物工程与应用微生物

CiteScore

10.00

自引率

4.00%

发文量

535

审稿时长

2 months

期刊介绍： Applied Microbiology and Biotechnology focusses on prokaryotic or eukaryotic cells, relevant enzymes and proteins; applied genetics and molecular biotechnology; genomics and proteomics; applied microbial and cell physiology; environmental biotechnology; process and products and more. The journal welcomes full-length papers and mini-reviews of new and emerging products, processes and technologies.