A novel electrochemical sensor based on CS/ACK@CeO2/GCE for high selectivity and sensitivity analysis of baicalin in complex samples

IF 2.6 4区化学 Q3 ELECTROCHEMISTRY

Journal of Solid State Electrochemistry Pub Date : 2024-11-29 DOI:10.1007/s10008-024-06143-7

Bolu Sun, Chengyang Gao, Haiying He, Dai Li, Miao Zhou, Xuanxiu Da, Ke Sun, Guolin Chai, Quan Hao, Fangdi Hu, Lingbin Kong

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引用次数: 0

Abstract

Baicalin is an index component used for the quality evaluation of Scutellaria baicalensis Georgi with significant anticancer activity. It is very important to develop a highly selective and sensitive method for the detection of baicalin in complex samples, which is used for standardized planting, harvesting, and processing of Scutellaria baicalensis, quality control of Scutellaria baicalensis herbs and products. Based on this, a novel electrochemical sensor based on CS/ACK@CeO₂-NPs composite material was constructed for the rapid and sensitive detection of baicalin in complex samples. It is noteworthy that cerium oxide nanoparticles (CeO₂-NPs) were loaded on the KMnO₄-modified activated carbon (ACK) and used in the construction of electrochemical sensors for the first time. The number of micropores of ACK was significantly increased, and the specific surface area of the material was effectively increased. The combination of ACK with cerium oxide nanoparticles (CeO₂-NPs) avoided the agglomeration of CeO₂-NPs, which produced a significant synergistic effect, increased the electron transfer rate, and provided more active adsorption sites for electron transfer. In addition, chitosan (CS) has good film-forming performance, so adding CS to the ACK@CeO₂-NPs system not only improves the film-forming performance and mechanical properties but also makes the constructed sensor more stable and sensitive. After optimizing the conditions, the test displayed good linearity in the concentration range (2.24 × 10⁻⁴ ~ 4.48 × 10⁻⁷ mol/L) of baicalin with the lowest detection limit of 4.81 × 10⁻⁹ mol/L (S/N = 3) when it is used for the detection of baicalin in complex samples. This method provides a new approach for the rapid and sensitive detection of baicalin in complex samples. The application of electrochemical analysis techniques to the instant monitoring of active or indicator components in the materials of traditional Chinese medicine (TCM) and their preparations is expected to provide a sensitive, rapid, and reliable monitoring and analysis technique for the quality control of TCM and their products throughout their life cycle.

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基于CS/ACK@CeO2/GCE的新型电化学传感器用于黄芩苷的高选择性和高灵敏度分析

黄芩苷是黄芩质量评价的指标性成分，具有显著的抗癌活性。开发一种高选择性、高灵敏度的方法来检测复杂样品中的黄芩苷非常重要，它可用于黄芩的标准化种植、收获和加工，以及黄芩药材和产品的质量控制。在此基础上，构建了一种基于 CS/ACK@CeO2-NPs 复合材料的新型电化学传感器，用于快速灵敏地检测复合样品中的黄芩苷。值得注意的是，氧化铈纳米颗粒（CeO2-NPs）被负载在 KMnO4 改性活性炭（ACK）上，并首次用于构建电化学传感器。ACK 的微孔数量显著增加，材料的比表面积也得到了有效提高。ACK 与氧化铈纳米颗粒（CeO2-NPs）的结合避免了 CeO2-NPs 的团聚，产生了显著的协同效应，提高了电子转移率，为电子转移提供了更多的活性吸附位点。此外，壳聚糖（CS）具有良好的成膜性能，因此在 ACK@CeO2-NPs 体系中添加 CS 不仅能提高成膜性能和机械性能，还能使构建的传感器更加稳定和灵敏。经优化条件后，该方法在黄芩苷的浓度范围（2.24 × 10-4 ~ 4.48 × 10-7 mol/L）内线性关系良好，用于复杂样品中黄芩苷的检测时，最低检出限为 4.81 × 10-9 mol/L（信噪比为 3）。该方法为快速灵敏地检测复杂样品中的黄芩苷提供了一种新方法。将电化学分析技术应用于中药及其制剂材料中活性成分或指示剂成分的即时监测，有望为中药及其产品整个生命周期的质量控制提供灵敏、快速、可靠的监测和分析技术。

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来源期刊

Journal of Solid State Electrochemistry 工程技术-电化学

CiteScore

4.80

自引率

4.00%

发文量

227

审稿时长

4.1 months

期刊介绍： The Journal of Solid State Electrochemistry is devoted to all aspects of solid-state chemistry and solid-state physics in electrochemistry. The Journal of Solid State Electrochemistry publishes papers on all aspects of electrochemistry of solid compounds, including experimental and theoretical, basic and applied work. It equally publishes papers on the thermodynamics and kinetics of electrochemical reactions if at least one actively participating phase is solid. Also of interest are articles on the transport of ions and electrons in solids whenever these processes are relevant to electrochemical reactions and on the use of solid-state electrochemical reactions in the analysis of solids and their surfaces. The journal covers solid-state electrochemistry and focusses on the following fields: mechanisms of solid-state electrochemical reactions, semiconductor electrochemistry, electrochemical batteries, accumulators and fuel cells, electrochemical mineral leaching, galvanic metal plating, electrochemical potential memory devices, solid-state electrochemical sensors, ion and electron transport in solid materials and polymers, electrocatalysis, photoelectrochemistry, corrosion of solid materials, solid-state electroanalysis, electrochemical machining of materials, electrochromism and electrochromic devices, new electrochemical solid-state synthesis. The Journal of Solid State Electrochemistry makes the professional in research and industry aware of this swift progress and its importance for future developments and success in the above-mentioned fields.