LINC02679 regulates TRIML2 to promote gastric cancer proliferation and invasion via targeting miR-5004-3p

Abstract

As a key protein, Tripartite motif family-like 2 (TRIML2) is crucial to the p53-mediated apoptosis and is correlated with tumorigenesis. Emerging evidence showed that long non-coding RNAs (lncRNAs) play roles in the malignant progression of gastric cancer (GC). However, the function and underlying mechanism of LINC02679 in GC are still unclear. In this study, we detected the differentially expressed lncRNA, LINC02679, which was associated with the progression of GC. Herein, we showed that LINC02679 was overexpressed in GC tissues and correlated with poor prognosis, which aggravated GC proliferation, migration, and invasion. Mechanistically, LINC02679 sponged miR-5004-3p to promote the expression of TRIML2, regulating GC tumorigenesis and progression. Moreover, TRIML2 affected the proliferation, migration, and invasion of GC cells through TGF-β1/Smads signaling pathway. Overall, our findings proved a new mechanism and provided a promising strategy for precise therapy of GC by targeting LINC02679.