Hui Sin Lim , Christopher J. Serpell , Satoshi Ogawa , Yong Yu Hu , Eng Hwa Wong
{"title":"From Fins to Furs: Unlocking the Therapeutic Potential of Animal-derived Bioactives for Wound Care","authors":"Hui Sin Lim , Christopher J. Serpell , Satoshi Ogawa , Yong Yu Hu , Eng Hwa Wong","doi":"10.1016/j.medidd.2025.100206","DOIUrl":null,"url":null,"abstract":"<div><div>Animal-derived products, such as organs, secretions, and mucus, have been part and parcel of traditional medicine and are often overlooked in the modern healthcare system. Nevertheless, researchers have begun to explore the untapped potential of bioactive compounds from marine organisms, reptiles, amphibians, and insects, thus offering innovative solutions for wound care. This review delved into the medicinal properties of animal-based bioactive compounds in wound healing based on in vitro and in vivo studies. A comparative analysis of the empirical evidence was performed to determine the benefits and limitations of animal-derived bioactive compounds. In summary, the literature suggests that animal-derived products could regulate biological pathways involved in inflammation and tissue regeneration. Clinical trials are underway to affirm the feasibility and safety of these compounds for human health applications.</div></div>","PeriodicalId":33528,"journal":{"name":"Medicine in Drug Discovery","volume":"26 ","pages":"Article 100206"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine in Drug Discovery","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S259009862500003X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Animal-derived products, such as organs, secretions, and mucus, have been part and parcel of traditional medicine and are often overlooked in the modern healthcare system. Nevertheless, researchers have begun to explore the untapped potential of bioactive compounds from marine organisms, reptiles, amphibians, and insects, thus offering innovative solutions for wound care. This review delved into the medicinal properties of animal-based bioactive compounds in wound healing based on in vitro and in vivo studies. A comparative analysis of the empirical evidence was performed to determine the benefits and limitations of animal-derived bioactive compounds. In summary, the literature suggests that animal-derived products could regulate biological pathways involved in inflammation and tissue regeneration. Clinical trials are underway to affirm the feasibility and safety of these compounds for human health applications.