Comparison of Thiel-fixed and fresh-frozen temporal bon biomechanics with dynamic synchrotron-based X-ray imaging

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2025-04-08 DOI:10.1016/j.clinbiomech.2025.106522

Margaux Schmeltz , Aleksandra Ivanovic , Christian M. Schlepütz , Wilhelm Wimmer , Anne Bonnin , Lukas Anschuetz

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引用次数: 0

Abstract

Background

The Thiel embalming method offers lifelike tissue preservation, yet its suitability for biomechanical studies remains debated.

Methods

Here, we investigated two human temporal bones, one Thiel-fixed and one fresh-frozen, using dynamic synchrotron-based X-ray imaging under acoustic stimulation.

Findings

Both specimens exhibited a linear response at the umbo, but the Thiel-fixed specimen displayed discontinuity after the incudo-malleolar joint, suggesting ossicular chain stiffening. Our findings align well with previous studies indicating potential tissue degradation induced by Thiel-embalming.

Interpretation

These observations question the use of Thiel-fixed human specimens for biomechanical measurements on the middle ear, especially using dynamic synchrotron-based X-ray imaging. They emphasize the need for further assessment of the impact of Thiel-embalming methods on tissue mechanics.

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thiel固定和新鲜冷冻时间碳生物力学与动态同步辐射x射线成像的比较

Thiel防腐方法提供了逼真的组织保存，但其在生物力学研究中的适用性仍然存在争议。方法利用声刺激下的动态同步辐射x射线成像技术，研究了两组人颞骨，一组为thiel固定骨，另一组为新鲜冷冻骨。结果：两种标本在脐部均表现为线性响应，但蒂尔固定标本在包括踝关节后表现为不连续性，提示听骨链硬化。我们的发现与先前的研究一致，表明thiel防腐可能导致组织降解。这些观察结果对使用thiel固定的人体标本进行中耳生物力学测量提出了质疑，特别是使用基于动态同步加速器的x射线成像。他们强调需要进一步评估thiel防腐方法对组织力学的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.