Epilepsy-related mortality: A cross-sectional study in a tertiary center in Riyadh, Saudi Arabia

IF 2.7 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy Pub Date : 2025-03-28 DOI:10.1016/j.seizure.2025.03.018

Ali Alanazi , Abdulaziz A. Aldbas , Reem S. Alamri , Joza D Alenzi , Emad Masuadi

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引用次数: 0

Abstract

Objective

People with epilepsy (PWE) have higher likelihood of dying prematurely compared to the general population. However, data on epilepsy mortality in some regions of the world are deficient or completely absent. The aim of this study was to investigate epilepsy-related deaths in PWE in a tertiary care center in Riyadh, Saudi Arabia.

Methods

PWE who expired in the period from 2016 to 2020 at King Abdulaziz Medical City in Riyadh, Saudi Arabia were included. Demographic data, epilepsy classification, and causes of death were retrieved from the patients’ electronic medical records, and death certificates. Death causes were classified based on Devinsky's classification.

Results

We found that 145 PWE died during the study period. The median age at death was 66 years, with an interquartile range of 49–78. Half of the patients who died were male (50.3 %). Of the 145 deaths, 93 (64.1 %) were unrelated to epilepsy, 27 (18.6 %) were due to underlying neurological disease, 15 (10.3 %) were directly due to epilepsy, 7 (4.8 %) were indirectly due to epilepsy, and 3 (2.1 %) were due to acute symptomatic seizures. Sudden unexpected death in epilepsy (SUDEP) has never been recorded as a cause of death in any of the cases.

Significance

Epilepsy-related deaths are largely overlooked by physicians who document death certificates. More efforts are needed to increase awareness among physicians about SUDEP and epilepsy-related mortality.

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癫痫相关死亡率：沙特阿拉伯利雅得三级中心的横断面研究

目的与一般人群相比，癫痫患者（PWE）过早死亡的可能性更高。然而，世界上一些区域关于癫痫死亡率的数据缺乏或完全没有。本研究的目的是调查沙特阿拉伯利雅得一家三级保健中心PWE中与癫痫相关的死亡。方法选取2016 - 2020年在沙特阿拉伯利雅得阿卜杜勒阿齐兹国王医疗城（King Abdulaziz Medical City）死亡的spwe。从患者的电子病历和死亡证明中检索人口统计数据、癫痫分类和死亡原因。死因是根据德文斯基的分类分类的。结果145例PWE在研究期间死亡。死亡年龄中位数为66岁，四分位数范围为49-78岁。半数死亡患者为男性（50.3%）。145例死亡中，93例（64.1%）与癫痫无关，27例（18.6%）死于潜在的神经系统疾病，15例（10.3%）直接死于癫痫，7例（4.8%）间接死于癫痫，3例（2.1%）死于急性症状性发作。癫痫猝死（SUDEP）从未被记录为任何病例的死亡原因。癫痫相关的死亡在很大程度上被记录死亡证明的医生所忽视。需要更多的努力来提高医生对SUDEP和癫痫相关死亡率的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seizure-European Journal of Epilepsy 医学-临床神经学

CiteScore

5.60

自引率

6.70%

发文量

231

审稿时长

34 days

期刊介绍： Seizure - European Journal of Epilepsy is an international journal owned by Epilepsy Action (the largest member led epilepsy organisation in the UK). It provides a forum for papers on all topics related to epilepsy and seizure disorders.